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Ischaemic cardiomyopathy: pathophysiology, assessment and the role of revascularisation

Heart (British Cardiac Society), 2016-03, Vol.102 (5), p.397-406 [Peer Reviewed Journal]

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing ;Copyright: 2016 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing ;ISSN: 1355-6037 ;EISSN: 1468-201X ;DOI: 10.1136/heartjnl-2015-308037 ;PMID: 26740480

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Title:
Ischaemic cardiomyopathy: pathophysiology, assessment and the role of revascularisation
Author: Briceno, Natalia ; Schuster, Andreas ; Lumley, Matthew ; Perera, Divaka
Subjects: Accreditation ; Acute coronary syndromes ; Cardiology ; Cardiomyopathies - diagnosis ; Cardiomyopathies - etiology ; Cardiomyopathies - mortality ; Cardiomyopathies - physiopathology ; Cardiomyopathies - therapy ; Cardiomyopathy ; Cardiovascular disease ; Coronary Circulation ; Diagnostic Imaging - methods ; Drug therapy ; Education ; Heart attacks ; Heart failure ; Hibernation ; Humans ; Medical imaging ; Metabolism ; Mortality ; Myocardial Ischemia - complications ; Myocardial Ischemia - diagnosis ; Myocardial Ischemia - mortality ; Myocardial Ischemia - physiopathology ; Myocardial Ischemia - therapy ; Myocardial Revascularization - adverse effects ; Myocardial Revascularization - methods ; Myocardial Revascularization - mortality ; Myocardium - pathology ; Predictive Value of Tests ; Risk Factors ; Rodents ; Tissue Survival ; Treatment Outcome
Is Part Of: Heart (British Cardiac Society), 2016-03, Vol.102 (5), p.397-406
Description: Ischaemic cardiomyopathy: adaptation versus pathology ICM consists of a spectrum of pathophysiological states that relate to perfusion contraction matching and mismatching. 15 An ischaemia model in conscious dogs in the 1980s demonstrated a correlation between myocardial blood flow and regional contractile function, with only small reductions in flow resulting in significant reductions in regional myocardial function. 16 It has also been shown that coronary flow reserve is reduced and changes in metabolism are seen in areas of myocardium subtended by normal coronary arteries in patients with chronic stable angina secondary to coronary stenoses, 17 indicating that areas of myocardium remote from ischaemia are also impacted. Many historical observational studies have shown a mortality benefit in patients with ICM undergoing revascularisation, however the largest randomised study to date, STICH, was negative in terms of its primary end point. [...]at present there are no randomised trial data to support revascularisation in patients with ICM who do not have significant angina or an acute coronary syndrome.
Publisher: England: BMJ Publishing Group LTD
Language: English
Identifier: ISSN: 1355-6037
EISSN: 1468-201X
DOI: 10.1136/heartjnl-2015-308037
PMID: 26740480
Source: MEDLINE
ProQuest Central

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Ischaemic cardiomyopathy: pathophysiology, assessment and the role of revascularisation

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