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Epidemiology of COVID-19: A systematic review and meta-analysis of clinical characteristics, risk factors, and outcomes

Journal of Medical Virology, 2021-03, Vol.93 (3), p.1449 [Peer Reviewed Journal]

2020 Wiley Periodicals LLC. ;2020. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://novel-coronavirus.onlinelibrary.wiley.com ;EISSN: 1096-9071 ;DOI: 10.1002/jmv.26424 ;PMID: 32790106

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  • Title:
    Epidemiology of COVID-19: A systematic review and meta-analysis of clinical characteristics, risk factors, and outcomes
  • Author: Li, Jie ; Huang, Daniel Q ; Zou, Biyao ; Yang, Hongli ; Hui, Wan Zi ; Rui, Fajuan ; Yee, Natasha Tang Sook ; Liu, Chuanli ; Nerurkar, Sanjna Nilesh ; Kai, Justin Chua Ying ; Teng, Margaret Li Peng ; Li, Xiaohe ; Zeng, Hua ; Borghi, John A ; Henry, Linda ; Cheung, Ramsey ; Nguyen, Mindie H
  • Subjects: Comorbidity ; COVID-19 - epidemiology ; COVID-19 - mortality ; COVID-19 - physiopathology ; Female ; Hospitalization - statistics & numerical data ; Humans ; Male ; Risk Factors ; Severity of Illness Index
  • Is Part Of: Journal of Medical Virology, 2021-03, Vol.93 (3), p.1449
  • Description: Coronavirus disease 2019 (COVID-19) has become a pandemic, but its reported characteristics and outcomes vary greatly amongst studies. We determined pooled estimates for clinical characteristics and outcomes in COVID-19 patients including subgroups by disease severity (based on World Health Organization Interim Guidance Report or Infectious Disease Society of America/American Thoracic Society criteria) and by country/region. We searched Pubmed, Embase, Scopus, Cochrane, Chinese Medical Journal, and preprint databases from 1 January 2020 to 6 April 2020. Studies of laboratory-confirmed COVID-19 patients with relevant data were included. Two reviewers independently performed study selection and data extraction. From 6007 articles, 212 studies from 11 countries/regions involving 281 461 individuals were analyzed. Overall, mean age was 46.7 years, 51.8% were male, 22.9% had severe disease, and mortality was 5.6%. Underlying immunosuppression, diabetes, and malignancy were most strongly associated with severe COVID-19 (coefficient =  53.9, 23.4, 23.4, respectively, all P < .0007), while older age, male gender, diabetes, and hypertension were also associated with higher mortality (coefficient = 0.05 per year, 5.1, 8.2, 6.99, respectively; P = .006-.0002). Gastrointestinal (nausea, vomiting, abdominal pain) and respiratory symptoms (shortness of breath, chest pain) were associated with severe COVID-19, while pneumonia and end-organ failure were associated with mortality. COVID-19 is associated with a severe disease course in about 23% and mortality in about 6% of infected persons. Individuals with comorbidities and clinical features associated with severity should be monitored closely, and preventive efforts should especially target those with diabetes, malignancy, and immunosuppression.
  • Publisher: United States: John Wiley & Sons, Inc
  • Language: English
  • Identifier: EISSN: 1096-9071
    DOI: 10.1002/jmv.26424
    PMID: 32790106
  • Source: Coronavirus Research Database
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