skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Polycystic ovary syndrome and risk of stillbirth: A nationwide register-based study

BJOG : an international journal of obstetrics and gynaecology, 2021-12, Vol.128 (13), p.2073 [Peer Reviewed Journal]

ISSN: 1471-0528 ;ISSN: 1470-0328 ;EISSN: 1471-0528 ;DOI: 10.1111/1471-0528.16890

Digital Resources/Online E-Resources

Citations Cited by
  • Title:
    Polycystic ovary syndrome and risk of stillbirth: A nationwide register-based study
  • Author: Valgeirsdóttir, Heiddis ; Kunovac Kallak, Theodora ; Sundström Poromaa, Inger ; Jonsson, Maria ; Roos, Nathalie ; Lindström, Linda ; Wikström, Anna-Karin
  • Subjects: Medicin och hälsovetenskap ; Obstetrics and Gynaecology ; Obstetrik och gynekologi ; PCOS ; pregnancy complications ; stillbirth
  • Is Part Of: BJOG : an international journal of obstetrics and gynaecology, 2021-12, Vol.128 (13), p.2073
  • Description: Objective To investigate whether polycystic ovary syndrome (PCOS) is associated with increased risk of stillbirth and whether any such association is linked to PCOS with a severe hyperandrogenic profile. Design Nationwide register-based cohort study. Setting Sweden. Population The cohort consisted of women giving birth to singleton infants in 1997–2015. All women with a diagnosis of PCOS in the period 1997–2017 and a randomly selected reference group of women without PCOS diagnosis were included. PCOS with a severe hyperandrogenic profile was defined as a PCOS diagnosis with at least two dispensations of prescribed anti-androgens during 2005–2017. Methods The risk of stillbirth in women with PCOS was estimated through multiple logistic regression, using women without PCOS as a reference. Risks were expressed as adjusted odds ratios (aORs) with 95% confidence intervals (95% CIs), adjusted for maternal age, parity, body mass index, type-1 diabetes, educational level and country of birth. Main outcome measures Stillbirth, at ≥22 weeks of gestation in 2008–2015 and at ≥28 weeks of gestation in 1997–2007. Results Compared with women without PCOS ( n  = 241 750), women with PCOS ( n  = 41 851) had a 50% increased risk of stillbirth (aOR 1.50, 95% CI 1.28–1.77). The incidence of stillbirth in women with PCOS was particularly increased at term. Women with PCOS and a severe hyperandrogenic profile ( n  = 13 713) did not have a stronger association with stillbirth than women with PCOS who did not have such a profile. Conclusions PCOS is associated with stillbirth and should be considered as a possible risk factor in antenatal care. Further research is warranted to investigate possible causal mechanisms.
  • Language: English
  • Identifier: ISSN: 1471-0528
    ISSN: 1470-0328
    EISSN: 1471-0528
    DOI: 10.1111/1471-0528.16890
  • Source: SWEPUB Freely available online
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait