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Long Noncoding RNAs: Emerging Stars in Gene Regulation, Epigenetics and Human Disease

ChemMedChem, 2014-09, Vol.9 (9), p.1932-1956 [Peer Reviewed Journal]

2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim ;2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. ;ISSN: 1860-7179 ;EISSN: 1860-7187 ;DOI: 10.1002/cmdc.201300534 ;PMID: 24677606

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  • Title:
    Long Noncoding RNAs: Emerging Stars in Gene Regulation, Epigenetics and Human Disease
  • Author: Bhan, Arunoday ; Mandal, Subhrangsu S.
  • Subjects: Disease ; drugs targets ; Epigenesis, Genetic ; epigenetics ; Gene Expression Regulation - physiology ; gene regulation ; Genomics ; human diseases ; Humans ; long noncoding RNA ; Medical research ; noncoding RNA ; RNA, Long Noncoding - genetics
  • Is Part Of: ChemMedChem, 2014-09, Vol.9 (9), p.1932-1956
  • Description: Noncoding RNAs (ncRNAs) are classes of transcripts that are encoded by the genome and transcribed but never get translated into proteins. Though not translated into proteins, ncRNAs play pivotal roles in a variety of cellular functions. Here, we review the functions of long noncoding RNAs (lncRNAs) and their implications in various human diseases. Increasing numbers of studies demonstrate that lncRNAs play critical roles in regulation of protein‐coding genes, maintenance of genomic integrity, dosage compensation, genomic imprinting, mRNA processing, cell differentiation, and development. Misregulation of lncRNAs is associated with a variety of human diseases, including cancer, immune and neurological disorders. Different classes of lncRNAs, their functions, mechanisms of action, and associations with different human diseases are summarized in detail, highlighting their as yet untapped potential in therapy. More than just junk: Long noncoding RNAs (lncRNAs) functionally interact with the genome and modulate chromatin dynamics, gene expression, and epigenetics. Misregulation of lncRNAs is associated with a variety of human diseases, including cancer, immune and neurological disorders. The involvement of lncRNAs in diseases and their potential in therapy is reviewed.
  • Publisher: Weinheim: WILEY-VCH Verlag
  • Language: English;German
  • Identifier: ISSN: 1860-7179
    EISSN: 1860-7187
    DOI: 10.1002/cmdc.201300534
    PMID: 24677606
  • Source: MEDLINE
    Alma/SFX Local Collection
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