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Reactogenicity after the first and second doses of BNT162b2 mRNA coronavirus disease vaccine: a single-center study

Clinical and Experimental Vaccine Research , 2021, 10(3), , pp.282-294 [Peer Reviewed Journal]

Korean Vaccine Society. ;2021. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Korean Vaccine Society. 2021 Korean Vaccine Society ;ISSN: 2287-3651 ;EISSN: 2287-366X ;DOI: 10.7774/cevr.2021.10.3.282 ;PMID: 34703812

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  • Title:
    Reactogenicity after the first and second doses of BNT162b2 mRNA coronavirus disease vaccine: a single-center study
  • Author: Kang, Yu Min ; Lim, Jaegyun ; Choe, Kang-Won ; Lee, Ki-Deok ; Jo, Dong Ho ; Kim, Moon Jung ; Kim, Jong Min ; Kim, Kwang Nam
  • Subjects: Age groups ; Analgesics ; Coronaviruses ; COVID-19 Special ; COVID-19 vaccines ; Drug dosages ; Edema ; Emergency medical care ; FDA approval ; Herd immunity ; Medical personnel ; Muscle pain ; Severe acute respiratory syndrome coronavirus 2 ; Statistical analysis ; Urticaria ; 예방의학
  • Is Part Of: Clinical and Experimental Vaccine Research , 2021, 10(3), , pp.282-294
  • Description: This study was conducted to determine differences in adverse events associated with the first and second doses of the BNT162b2 coronavirus disease 2019 vaccine based on the age and sex of recipients. An online survey on the post-vaccination adverse events of healthcare workers was conducted from March 2021 to April 2021. The differences in the types of adverse events, including severity, onset time, and duration of symptoms, and how the adverse events were dealt with by the patient were analyzed based on the age and sex. The profiles of adverse events were compared after the first and second vaccination doses. Among the 131 participants who participated in the online survey out of 208 vaccine recipients, 43 and 80 recipients of the BNT162b2 vaccine experienced adverse events after the first and second dose, respectively. No sex-related differences were observed in the profiles of adverse events in vaccinated recipients. The overall frequency of adverse events did not differ based on age after the first dose. After the second dose, the frequency of adverse events, including both local and systemic reactions was significantly higher in the younger age group than in the older age group. The BNT162b2 vaccine resulted in a higher frequency of adverse events after the second dose than after the first dose especially in the younger age group; however, no sex-related differences associated with these adverse events were observed.
  • Publisher: Korea (South): Korean Vaccine Society
  • Language: English
  • Identifier: ISSN: 2287-3651
    EISSN: 2287-366X
    DOI: 10.7774/cevr.2021.10.3.282
    PMID: 34703812
  • Source: PubMed Central
    KoreaMed Open Access
    Coronavirus Research Database
    ProQuest Central
    DOAJ Directory of Open Access Journals
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