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MAFLD Predicts the Risk of Cardiovascular Disease Better than NAFLD in Asymptomatic Subjects with Health Check-Ups

Digestive diseases and sciences, 2022-10, Vol.67 (10), p.4919-4928 [Peer Reviewed Journal]

The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 ;2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. ;COPYRIGHT 2022 Springer ;The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. ;ISSN: 0163-2116 ;EISSN: 1573-2568 ;DOI: 10.1007/s10620-022-07508-6 ;PMID: 35579799

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Title:
MAFLD Predicts the Risk of Cardiovascular Disease Better than NAFLD in Asymptomatic Subjects with Health Check-Ups
Author: Kim, Hyoeun ; Lee, Chan Joo ; Ahn, Sang Hoon ; Lee, Kwan Sik ; Lee, Byoung Kwon ; Baik, Su Jung ; Kim, Seung Up ; Lee, Jung Il
Subjects: Asymptomatic ; Biochemistry ; Calcium ; Cardiovascular disease ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Coronary Artery Disease - complications ; Coronary heart disease ; Coronary vessels ; Female ; Gastroenterology ; Hepatology ; Humans ; Hypertension ; Liver ; Liver diseases ; Male ; Medical colleges ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Non-alcoholic Fatty Liver Disease - complications ; Non-alcoholic Fatty Liver Disease - diagnosis ; Non-alcoholic Fatty Liver Disease - epidemiology ; Obesity - epidemiology ; Oncology ; Original Article ; Retrospective Studies ; Risk Factors ; Transplant Surgery ; Vein & artery diseases
Is Part Of: Digestive diseases and sciences, 2022-10, Vol.67 (10), p.4919-4928
Description: Background and Aim Metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed to compensate for the conventional concept of nonalcoholic fatty liver disease (NAFLD). We investigated the superiority of MAFLD versus NAFLD in predicting the risk of atherosclerotic cardiovascular disease (ASCVD). Methods A total of 2,144 subjects without a history of ASCVD, who underwent a comprehensive medical health check-up, were selected for the study. The associations between fatty liver status and coronary risk surrogates, such as coronary artery calcium score (CACS), coronary artery disease, quantitative stenosis grade, and 10-year ASCVD risk, were analyzed. Results MAFLD and NAFLD were identified in 995 (46.4%) and 891 (41.6%) subjects, respectively. Subjects with MAFLD or NAFLD were more likely to be male and had a significantly higher prevalence of central obesity, obesity, hypertension, diabetes, and dyslipidemia (all, p < 0.05) than their counterparts. In terms of coronary risk surrogates, the MAFLD or NAFLD population had a significantly higher proportion of subjects with CACS > 100, coronary artery disease, higher grade of coronary artery stenosis, and higher 10-year ASCVD risk (all, p < 0.05) than their counterparts. Multivariable logistic regression models showed an independent association between MAFLD/NAFLD and coronary risk surrogates (all, p < 0.05). However, NAFLD only, defined as ‘NAFLD, but not MAFLD,’ was not associated with an increased coronary risk, compared to MAFLD. Conclusions Although both MAFLD and NAFLD discriminated different ASCVD risks, MAFLD predicted the risk of ASCVD better than NAFLD in asymptomatic subjects who underwent medical health check-ups.
Publisher: New York: Springer US
Language: English
Identifier: ISSN: 0163-2116
EISSN: 1573-2568
DOI: 10.1007/s10620-022-07508-6
PMID: 35579799
Source: MEDLINE
ProQuest Central

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MAFLD Predicts the Risk of Cardiovascular Disease Better than NAFLD in Asymptomatic Subjects with Health Check-Ups

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