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Rapid decline in the susceptibility of Plasmodium falciparum to dihydroartemisinin-piperaquine in the south of Vietnam

Malaria journal, 2017-01, Vol.16 (1), p.27-27, Article 27 [Peer Reviewed Journal]

COPYRIGHT 2017 BioMed Central Ltd. ;Copyright BioMed Central 2017 ;2017. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2017 ;ISSN: 1475-2875 ;EISSN: 1475-2875 ;DOI: 10.1186/s12936-017-1680-8 ;PMID: 28086775

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Title:
Rapid decline in the susceptibility of Plasmodium falciparum to dihydroartemisinin-piperaquine in the south of Vietnam
Author: Thanh, Ngo Viet ; Thuy-Nhien, Nguyen ; Tuyen, Nguyen Thi Kim ; Tong, Nguyen Thanh ; Nha-Ca, Nguyen Thuy ; Dong, Le Thanh ; Quang, Huynh Hong ; Farrar, Jeremy ; Thwaites, Guy ; White, Nicholas J ; Wolbers, Marcel ; Hien, Tran Tinh
Subjects: Adolescent ; Adult ; Analysis ; Antimalarials - pharmacology ; Antimalarials - therapeutic use ; Artemisinin ; Artemisinins - pharmacology ; Artemisinins - therapeutic use ; Asexuality ; Child ; Child, Preschool ; Deoxyribonucleic acid ; Dihydroartemisinin ; Disease susceptibility ; DNA ; Drug dosages ; Drug Resistance ; Endemic Diseases ; Failures ; Female ; Genetic testing ; Health aspects ; Human diseases ; Humans ; Incidence ; Laboratories ; Malaria ; Malaria, Falciparum - drug therapy ; Malaria, Falciparum - epidemiology ; Malaria, Falciparum - parasitology ; Male ; Microscopy ; Mutation ; Parasites ; Patients ; Plasmodium falciparum ; Plasmodium falciparum - drug effects ; Plasmodium falciparum - isolation & purification ; Prevention ; Quinolines - pharmacology ; Quinolines - therapeutic use ; Risk factors ; Surveillance ; Time Factors ; Treatment Failure ; Vector-borne diseases ; Vietnam - epidemiology ; Young Adult
Is Part Of: Malaria journal, 2017-01, Vol.16 (1), p.27-27, Article 27
Description: Artemisinin resistant Plasmodium falciparum has emerged in the countries of the Greater Mekong sub-region posing a serious threat to global malaria elimination efforts. The relationship of artemisinin resistance to treatment failure has been unclear. In annual studies conducted in three malaria endemic provinces in the south of Vietnam (Binh Phuoc, Ninh Thuan and Gia Lai) between 2011 and 2015, 489 patients with uncomplicated P. falciparum malaria were enrolled in detailed clinical, parasitological and molecular therapeutic response assessments with 42 days follow up. Patients received the national recommended first-line treatment dihydroartemisinin-piperaquine for three days. Over the 5 years the proportion of patients with detectable parasitaemia on day 3 rose steadily from 38 to 57% (P < 0.001). In Binh Phuoc province, the parasite clearance half-life increased from 3.75 h in 2011 to 6.60 h in 2015 (P < 0.001), while treatment failures rose from 0% in 2012 and 2013, to 7% in 2014 and 26% in 2015 (P < 0.001). Recrudescence was associated with in vitro evidence of artemisinin and piperaquine resistance. In the treatment failures cases of 2015, all 14 parasite isolates carried the C580Y Pfkelch 13 gene, marker of artemisinin resistance and 93% (13/14) of them carried exoE415G mutations, markers of piperaquine resistance. In the south of Vietnam recent emergence of piperaquine resistant P. falciparum strains has accelerated the reduced response to artemisinin and has led to treatment failure rates of up to 26% to dihydroartemisinin-piperaquine, Vietnam's current first-line ACT. Alternative treatments are urgently needed.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1475-2875
EISSN: 1475-2875
DOI: 10.1186/s12936-017-1680-8
PMID: 28086775
Source: Geneva Foundation Free Medical Journals at publisher websites
Springer Open Access
MEDLINE
PubMed Central
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

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Rapid decline in the susceptibility of Plasmodium falciparum to dihydroartemisinin-piperaquine in the south of Vietnam

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