Language:

Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

Nature (London), 2015-07, Vol.523 (7561), p.431-436 [Peer Reviewed Journal]

COPYRIGHT 2015 Nature Publishing Group ;COPYRIGHT 2015 Nature Publishing Group ;Copyright Nature Publishing Group Jul 23, 2015 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/nature14658 ;PMID: 26176913 ;CODEN: NATUAS

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy
Author: Kondo, Asami ; Shahpasand, Koorosh ; Mannix, Rebekah ; Qiu, Jianhua ; Moncaster, Juliet ; Chen, Chun-Hau ; Yao, Yandan ; Lin, Yu-Min ; Driver, Jane A ; Sun, Yan ; Wei, Shuo ; Luo, Man-Li ; Albayram, Onder ; Huang, Pengyu ; Rotenberg, Alexander ; Ryo, Akihide ; Goldstein, Lee E ; Pascual-Leone, Alvaro ; McKee, Ann C ; Meehan, William ; Zhou, Xiao Zhen ; Lu, Kun Ping
Subjects: Alzheimer Disease - complications ; Alzheimer Disease - prevention & control ; Alzheimers disease ; Animals ; Antibodies ; Antibodies, Monoclonal - immunology ; Antibodies, Monoclonal - pharmacology ; Antibodies, Monoclonal - therapeutic use ; Antibody Affinity ; Axons - metabolism ; Axons - pathology ; Brain - metabolism ; Brain - pathology ; Brain injuries ; Brain Injuries - complications ; Brain Injuries - metabolism ; Brain Injuries - pathology ; Brain Injuries - prevention & control ; Care and treatment ; Disease Models, Animal ; Epitopes - chemistry ; Epitopes - immunology ; Female ; Health aspects ; Humans ; Immunoglobulins ; Male ; Mice ; Nerve degeneration ; Neurodegeneration ; Phosphoproteins - antagonists & inhibitors ; Phosphoproteins - biosynthesis ; Phosphoproteins - immunology ; Phosphoproteins - toxicity ; Stress, Physiological ; Tau proteins ; tau Proteins - antagonists & inhibitors ; tau Proteins - biosynthesis ; tau Proteins - chemistry ; tau Proteins - immunology ; tau Proteins - toxicity ; Tauopathies - complications ; Tauopathies - metabolism ; Tauopathies - pathology ; Tauopathies - prevention & control ; Traumatic brain injury
Is Part Of: Nature (London), 2015-07, Vol.523 (7561), p.431-436
Description: Traumatic brain injury (TBI), characterized by acute neurological dysfunction, is one of the best known environmental risk factors for chronic traumatic encephalopathy and Alzheimer's disease, the defining pathologic features of which include tauopathy made of phosphorylated tau protein (P-tau). However, tauopathy has not been detected in the early stages after TBI, and how TBI leads to tauopathy is unknown. Here we find robust cis P-tau pathology after TBI in humans and mice. After TBI in mice and stress in vitro, neurons acutely produce cis P-tau, which disrupts axonal microtubule networks and mitochondrial transport, spreads to other neurons, and leads to apoptosis. This process, which we term 'cistauosis', appears long before other tauopathy. Treating TBI mice with cis antibody blocks cistauosis, prevents tauopathy development and spread, and restores many TBI-related structural and functional sequelae. Thus, cis P-tau is a major early driver of disease after TBI and leads to tauopathy in chronic traumatic encephalopathy and Alzheimer's disease. The cis antibody may be further developed to detect and treat TBI, and prevent progressive neurodegeneration after injury.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 0028-0836
EISSN: 1476-4687
DOI: 10.1038/nature14658
PMID: 26176913
CODEN: NATUAS
Source: ProQuest One Psychology
AUTh Library subscriptions: ProQuest Central
MEDLINE

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

COPYRIGHT 2015 Nature Publishing Group ;COPYRIGHT 2015 Nature Publishing Group ;Copyright Nature Publishing Group Jul 23, 2015 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/nature14658 ;PMID: 26176913 ;CODEN: NATUAS

Searching Remote Databases, Please Wait