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Intravitreal therapy for retinal diseases in Norway 2011–2015

Acta ophthalmologica (Oxford, England), 2020-05, Vol.98 (3), p.279-285 [Peer Reviewed Journal]

2019 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation. ;2019. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;info:eu-repo/semantics/openAccess ;ISSN: 1755-375X ;EISSN: 1755-3768 ;DOI: 10.1111/aos.14262 ;PMID: 31587508

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Title:
Intravitreal therapy for retinal diseases in Norway 2011–2015
Author: Kristiansen, Ivar Sønbø ; Haugli Bråten, Ragnhild ; Jørstad, Øystein Kalsnes ; Moe, Morten Carstens ; Sæther, Erik Magnus
Subjects: Adolescent ; Adult ; Age ; Age Distribution ; Aged ; Aged, 80 and over ; Angiogenesis Inhibitors - therapeutic use ; Child ; Child, Preschool ; Diabetes mellitus ; Diagnosis ; Edema ; EGFR ; Female ; Geographical variations ; Humans ; Infant ; Infant, Newborn ; intravitreal injection ; Intravitreal Injections - economics ; Intravitreal Injections - statistics & numerical data ; Macular degeneration ; Male ; Middle Aged ; Ranibizumab - therapeutic use ; Receptors, Vascular Endothelial Growth Factor - therapeutic use ; Recombinant Fusion Proteins - therapeutic use ; Registries ; Retina ; retinal disease ; Retinal Diseases - drug therapy ; Retinal Diseases - epidemiology ; statistics ; Vascular Endothelial Growth Factor A ; wet age‐related macular degeneration ; Young Adult
Is Part Of: Acta ophthalmologica (Oxford, England), 2020-05, Vol.98 (3), p.279-285
Description: Purpose During the past decade, intravitreally administered biologic drugs have advanced the treatment of retinal diseases, such as wet age‐related macular degeneration (AMD), diabetic macular oedema and retinal venous occlusions. The drugs as well as the necessary disease management imply considerable economic burden on healthcare systems. This Norwegian study documents the rates of use of intravitreal therapies and intercounty variation over a 5‐year period. Methods We collected data from the Norwegian Patient Register for all episodes of care encompassing intravitreal therapy during the period 2011–2015. For each episode, we received information on patient age, sex, county of residence, diagnosis and name of drug injected. Results During the study period, 21 277 patients had in total 236 857 episodes of care. The number of intravitreal injections doubled from 2011 to 2015, reaching 63 601 injections in 2015, of which 77% were for diagnosed wet AMD. In 2015, the age‐adjusted number of episodes varied from 19 to 55 per 1000 population aged 50+ across Norway's 19 counties. The age‐adjusted number of patients treated per 1000 population aged 50+ varied from 5.22 to 8.35. Conclusion The use of intravitreal injections increased rapidly with wet AMD as the most frequent diagnosis and with varying utilization across Norway's 19 counties. The causes of the varying use of intravitreal therapies could not be established but may reflect variation in disease prevalence, treatment capacity, travel distance to the nearest ophthalmic service and lack of national treatment guidelines. The geographic variation in utilization may challenge policy goals of equitable care and warrants further studies.
Publisher: England: Wiley Subscription Services, Inc
Language: English;Norwegian
Identifier: ISSN: 1755-375X
EISSN: 1755-3768
DOI: 10.1111/aos.14262
PMID: 31587508
Source: NORA Norwegian Open Research Archives

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Intravitreal therapy for retinal diseases in Norway 2011–2015

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