Language:

A Randomized Active-Controlled Study Comparing the Efficacy and Safety of Vernakalant to Amiodarone in Recent-Onset Atrial Fibrillation

Journal of the American College of Cardiology, 2011-01, Vol.57 (3), p.313-321 [Peer Reviewed Journal]

American College of Cardiology Foundation ;2011 American College of Cardiology Foundation ;2015 INIST-CNRS ;Copyright Â© 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. ;Copyright Elsevier Limited Jan 18, 2011 ;ISSN: 0735-1097 ;EISSN: 1558-3597 ;DOI: 10.1016/j.jacc.2010.07.046 ;PMID: 21232669 ;CODEN: JACCDI

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
A Randomized Active-Controlled Study Comparing the Efficacy and Safety of Vernakalant to Amiodarone in Recent-Onset Atrial Fibrillation
Author: Camm, A. John, MD ; Capucci, Alessandro, MD ; Hohnloser, Stefan H., MD ; Torp-Pedersen, Christian, MD ; Van Gelder, Isabelle C., MD ; Mangal, Brian, MSc ; Beatch, Gregory, PhD
Subjects: Acute coronary syndromes ; Acute Disease ; Aged ; amiodarone ; Amiodarone - adverse effects ; Amiodarone - therapeutic use ; Anisoles - adverse effects ; Anisoles - therapeutic use ; antiarrhythmics ; atrial fibrillation ; Atrial Fibrillation - drug therapy ; Atrial Fibrillation - physiopathology ; Biological and medical sciences ; Blood pressure ; Cardiac arrhythmia ; Cardiac dysrhythmias ; Cardiology. Vascular system ; Cardiomyopathy ; Cardiovascular ; Cardiovascular disease ; cardioversion ; Double-Blind Method ; Drug dosages ; Drug therapy ; Family medical history ; Female ; Follow-Up Studies ; Heart ; Heart attacks ; Heart failure ; Humans ; Internal Medicine ; Male ; Medical sciences ; Middle Aged ; Pyrrolidines - adverse effects ; Pyrrolidines - therapeutic use ; Sinuses ; Treatment Outcome ; vernakalant
Is Part Of: Journal of the American College of Cardiology, 2011-01, Vol.57 (3), p.313-321
Description: Objectives This randomized double-blind study compared the efficacy and safety of intravenous vernakalant and amiodarone for the acute conversion of recent-onset atrial fibrillation (AF). Background Intravenous vernakalant has effectively converted recent-onset AF and was well tolerated in placebo-controlled studies. Methods A total of 254 adult patients with AF (3 to 48 h duration) eligible for cardioversion were enrolled in the study. Patients received either a 10-min infusion of vernakalant (3 mg/kg) followed by a 15-min observation period and a second 10-min infusion (2 mg/kg) if still in AF, plus a sham amiodarone infusion, or a 60-min infusion of amiodarone (5 mg/kg) followed by a maintenance infusion (50 mg) over an additional 60 min, plus a sham vernakalant infusion. Results Conversion from AF to sinus rhythm within the first 90 min (primary end point) was achieved in 60 of 116 (51.7%) vernakalant patients compared with 6 of 116 (5.2%) amiodarone patients (p < 0.0001). Vernakalant resulted in rapid conversion (median time of 11 min in responders) and was associated with a higher rate of symptom relief compared with amiodarone (53.4% of vernakalant patients reported no AF symptoms at 90 min compared with 32.8% of amiodarone patients; p = 0.0012). Serious adverse events or events leading to discontinuation of study drug were uncommon. There were no cases of torsades de pointes, ventricular fibrillation, or polymorphic or sustained ventricular tachycardia. Conclusions Vernakalant demonstrated efficacy superior to amiodarone for acute conversion of recent-onset AF. Both vernakalant and amiodarone were safe and well tolerated in this study. (A Phase III Superiority Study of Vernakalant vs Amiodarone in Subjects With Recent Onset Atrial Fibrillation [AVRO]; NCT00668759 )
Publisher: New York, NY: Elsevier Inc
Language: English
Identifier: ISSN: 0735-1097
EISSN: 1558-3597
DOI: 10.1016/j.jacc.2010.07.046
PMID: 21232669
CODEN: JACCDI
Source: Freely Accessible Journals
MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

A Randomized Active-Controlled Study Comparing the Efficacy and Safety of Vernakalant to Amiodarone in Recent-Onset Atrial Fibrillation

Searching Remote Databases, Please Wait