Language:

Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease

Neurology, 2019-04, Vol.92 (15), p.e1669-e1677 [Peer Reviewed Journal]

2019 American Academy of Neurology ;2019 American Academy of Neurology. ;ISSN: 0028-3878 ;EISSN: 1526-632X ;DOI: 10.1212/WNL.0000000000007263 ;PMID: 30867275

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease
Author: Wong, Sau May ; Jansen, Jacobus F.A ; Zhang, C Eleana ; Hoff, Erik I ; Staals, Julie ; van Oostenbrugge, Robert J ; Backes, Walter H
Subjects: Aged ; Blood-Brain Barrier - diagnostic imaging ; Blood-Brain Barrier - pathology ; Cerebral Small Vessel Diseases - diagnostic imaging ; Cerebral Small Vessel Diseases - pathology ; Cerebrospinal Fluid Leak - pathology ; Cerebrovascular Circulation ; Cerebrovascular Disorders - diagnostic imaging ; Cerebrovascular Disorders - pathology ; Contrast Media ; Female ; Gadolinium ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; White Matter - diagnostic imaging
Is Part Of: Neurology, 2019-04, Vol.92 (15), p.e1669-e1677
Description: OBJECTIVETo investigate the link between blood-brain-barrier (BBB) permeability and cerebral blood flow (CBF) and the relation with white matter hyperintensities (WMH) in cerebral small vessel disease (cSVD). METHODSTwenty-seven patients with cSVD received dynamic susceptibility contrast and dynamic contrast-enhanced MRI to determine CBF and BBB permeability (expressed as leakage rate and volume), respectively. Structural MRI were segmented into normal-appearing white matter (NAWM) and WMH, for which a perilesional zone was defined. In these regions, we investigated the BBB permeability, CBF, and their relation using Pearson correlation r. RESULTSWe found a decrease in CBF of 2.2 mL/min/100 g (p < 0.01) and an increase in leakage volume of 0.7% (p < 0.01) per mm closer to the WMH in the perilesional zones. Lower CBF values correlated with higher leakage measures in the NAWM and WMH (−0.53 < r < −0.40, p < 0.05). This relation was also observed in the perilesional zones, which became stronger in the proximity of WMH (p = 0.03). CONCLUSIONBBB impairment and hypoperfusion appear in the WMH and NAWM, which increase in the proximity of the WMH, and are linked. Both BBB and CBF are regulated in the neurovascular unit (NVU) and the observed link might be due to the physiologic regulation mechanism of the NVU. This link may suggest an early overall deterioration of this unit.
Publisher: United States: American Academy of Neurology
Language: English
Identifier: ISSN: 0028-3878
EISSN: 1526-632X
DOI: 10.1212/WNL.0000000000007263
PMID: 30867275
Source: MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease

2019 American Academy of Neurology ;2019 American Academy of Neurology. ;ISSN: 0028-3878 ;EISSN: 1526-632X ;DOI: 10.1212/WNL.0000000000007263 ;PMID: 30867275

Searching Remote Databases, Please Wait