skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Two-photon AIE bio-probe with large Stokes shift for specific imaging of lipid droplets

Chemical science (Cambridge), 2017-08, Vol.8 (8), p.5440-5446 [Peer Reviewed Journal]

ISSN: 2041-6520 ;EISSN: 2041-6539 ;DOI: 10.1039/c7sc01400g ;PMID: 28970923

Full text available

Citations Cited by
  • Title:
    Two-photon AIE bio-probe with large Stokes shift for specific imaging of lipid droplets
  • Author: Jiang, Meijuan ; Gu, Xinggui ; Lam, Jacky W Y ; Zhang, Yilin ; Kwok, Ryan T K ; Wong, Kam Sing ; Tang, Ben Zhong
  • Is Part Of: Chemical science (Cambridge), 2017-08, Vol.8 (8), p.5440-5446
  • Description: Lipid droplets are dynamic organelles involved in various physiological processes and their detection is thus of high importance to biomedical research. Recent reports show that AIE probes for lipid droplet imaging have the superior advantages of high brightness, large Stokes shift and excellent photostability compared to commercial dyes but suffer from the problem of having a short excitation wavelength. In this work, an AIE probe, namely TPA-BI, was rationally designed and easily prepared from triphenylamine and imidazolone building blocks for the two-photon imaging of lipid droplets. TPA-BI exhibited TICT+AIE features with a large Stokes shift of up to 202 nm and a large two-photon absorption cross-section of up to 213 GM. TPA-BI was more suitable for two-photon imaging of the lipid droplets with the merits of a higher 3D resolution, lesser photobleaching, a reduced autofluorescence and deeper penetration in tissue slices than a commercial probe based on BODIPY 493/503, providing a promising imaging tool for lipid droplet tracking and analysis in biomedical research and clinical diagnosis.
  • Publisher: England
  • Language: English
  • Identifier: ISSN: 2041-6520
    EISSN: 2041-6539
    DOI: 10.1039/c7sc01400g
    PMID: 28970923
  • Source: PubMed Central
    DOAJ Directory of Open Access Journals
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait