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Ankylosing Spondylitis Disease Activity Score (ASDAS): defining cut-off values for disease activity states and improvement scores

Annals of the rheumatic diseases, 2011-01, Vol.70 (1), p.47-53 [Peer Reviewed Journal]

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions ;2015 INIST-CNRS ;Copyright: 2011 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions ;ISSN: 0003-4967 ;EISSN: 1468-2060 ;DOI: 10.1136/ard.2010.138594 ;PMID: 21068095 ;CODEN: ARDIAO

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  • Title:
    Ankylosing Spondylitis Disease Activity Score (ASDAS): defining cut-off values for disease activity states and improvement scores
  • Author: Machado, Pedro ; Landewé, Robert ; Lie, Elisabeth ; Kvien, Tore K ; Braun, Jürgen ; Baker, Daniel ; van der Heijde, Désirée
  • Subjects: Adult ; Antirheumatic Agents - therapeutic use ; Back pain ; Biological and medical sciences ; Bowel disease ; Clinical medicine ; Clinical trials ; Diseases of the osteoarticular system ; Diseases of the spine ; Epidemiologic Methods ; Female ; Health risk assessment ; Humans ; Inflammatory joint diseases ; Male ; Medical sciences ; Middle Aged ; Population ; Severity of Illness Index ; Spondylitis, Ankylosing - diagnosis ; Spondylitis, Ankylosing - drug therapy ; Studies ; Terminology as Topic ; Treatment Outcome
  • Is Part Of: Annals of the rheumatic diseases, 2011-01, Vol.70 (1), p.47-53
  • Description: Background The Ankylosing Spondylitis Disease Activity Score (ASDAS) is a new composite index to assess disease activity in ankylosing spondylitis (AS). It fulfils important aspects of truth, feasibility and discrimination. Criteria for disease activity states and improvement scores are important for use in clinical practice, observational studies and clinical trials and so far have not been developed for the ASDAS. Objective To determine clinically relevant cut-off values for disease activity states and improvement scores using the ASDAS. Methods For the selection of cut-offs data from the Norwegian disease modifying antirheumatic drug (NOR-DMARD) registry, a cohort of patients with AS starting conventional or biological DMARDs, were used. Receiver operating characteristic analysis against several external criteria was performed and several approaches to determine the optimal cut-offs used. The final choice was made on clinical and statistical grounds, after debate and voting by Assessment of SpondyloArthritis international Society members. Crossvalidation was performed in NOR-DMARD and in Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy, a database of patients with AS participating in a randomised placebo-controlled trial with a tumour necrosis factor blocker. Results Four disease activity states were chosen by consensus: inactive disease, moderate, high and very high disease activity. The three cut-offs selected to separate these states were: 1.3, 2.1 and 3.5 units. Selected cut-offs for improvement were: change ≥1.1 units for clinically important improvement and change ≥2.0 units for major improvement. Results of the crossvalidation strongly supported the cut-offs. Conclusions Cut-off values for disease activity states and improvement using the ASDAS have been developed. They proved to have external validity and a good performance compared to existing criteria.
  • Publisher: London: BMJ Publishing Group Ltd and European League Against Rheumatism
  • Language: English
  • Identifier: ISSN: 0003-4967
    EISSN: 1468-2060
    DOI: 10.1136/ard.2010.138594
    PMID: 21068095
    CODEN: ARDIAO
  • Source: MEDLINE
    Alma/SFX Local Collection
    ProQuest Central
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