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MicroRNAs as Regulators of Differentiation and Cell Fate Decisions

Cell stem cell, 2010-07, Vol.7 (1), p.36-41 [Peer Reviewed Journal]

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Title:
MicroRNAs as Regulators of Differentiation and Cell Fate Decisions
Author: Ivey, Kathryn N. ; Srivastava, Deepak
Subjects: Animals ; Biological and medical sciences ; Cell Cycle - genetics ; Cell Cycle - physiology ; Cell Differentiation - genetics ; Cell Differentiation - physiology ; Cell differentiation, maturation, development, hematopoiesis ; Cell Lineage - genetics ; Cell Lineage - physiology ; Cell physiology ; Embryonic Stem Cells - cytology ; Embryonic Stem Cells - metabolism ; Fundamental and applied biological sciences. Psychology ; Humans ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Models, Biological ; Molecular and cellular biology
Is Part Of: Cell stem cell, 2010-07, Vol.7 (1), p.36-41
Description: Unique expression domains, targets, and gain- and loss-of-function phenotypes of particular microRNAs have important implications for directed differentiation of stem cell populations and suppression of undesired cell types. We discuss this emerging topic, in part using muscle differentiation as a paradigm, and highlight common themes and unique modalities by which microRNAs exert their lineage-promoting or differentiation effects on multiple tissues.
Publisher: Cambridge, MA: Elsevier Inc
Language: English
Identifier: ISSN: 1934-5909
EISSN: 1875-9777
DOI: 10.1016/j.stem.2010.06.012
PMID: 20621048
Source: Cell Press Free Archives
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