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Associations between two genetic variants in NKX2-5 and risk of congenital heart disease in Chinese population: a meta-analysis

PloS one, 2013-08, Vol.8 (8), p.e70979 [Peer Reviewed Journal]

COPYRIGHT 2013 Public Library of Science ;COPYRIGHT 2013 Public Library of Science ;2013 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2013 Wang et al 2013 Wang et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0070979 ;PMID: 23936479

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Title:
Associations between two genetic variants in NKX2-5 and risk of congenital heart disease in Chinese population: a meta-analysis
Author: Wang, Zhenling ; Zou, Li ; Zhong, Rong ; Zhu, Beibei ; Chen, Wei ; Shen, Na ; Ke, Juntao ; Lou, Jiao ; Song, Ranran ; Miao, Xiao-Ping
Eisenberg, Leonard
Subjects: Asian Continental Ancestry Group - genetics ; Biology ; Cardiovascular disease ; China - epidemiology ; Cloning ; Congenital diseases ; Congenital heart disease ; Coronary artery disease ; Defects ; Education ; Environmental protection ; Epidemiology ; Genes ; Genetic disorders ; Genetic Predisposition to Disease ; Genetic transcription ; Genetic variance ; Health risks ; Heart ; Heart Defects, Congenital - epidemiology ; Heart Defects, Congenital - etiology ; Heart diseases ; Homeobox Protein Nkx-2.5 ; Homeodomain Proteins - genetics ; Humans ; Identification methods ; Laboratories ; Lists ; Maternal & child health ; Medical research ; Medicine ; Medicine, Experimental ; Meta-analysis ; Mutation ; Nkx2.5 protein ; Polymorphism, Single Nucleotide - genetics ; Population ; Public health ; Risk ; Risk Factors ; Science ; Sensitivity analysis ; Subgroups ; Systematic review ; Transcription factors ; Transcription Factors - genetics
Is Part Of: PloS one, 2013-08, Vol.8 (8), p.e70979
Description: NKX2-5 is a transcriptional factor, which plays an important role in heart formation and development. Two genetic variants in the coding region of NKX2-5, 63A>G (rs2277923) and 606G>C (rs3729753), have been investigated in the risk of congenital heart disease (CHD), although with inconsistent results. Thus, a meta-analysis was performed to clarify the associations between the two variants and CHD risk in the Chinese population. Relevant studies were identified by searching PubMed, ISI Web of Science and CNKI databases and by reviewing the reference lists of retrieved articles. Then, the data from eligible studies were combined in an allelic model. A total of 7 and 4 studies were ultimately included for 63A>G and 606G>C, respectively. The results of overall meta-analyses showed that significant association was detected for 63A>G (OR = 1.26, 95% CI = 1.02-1.56, P(heterogeneity )= 0.009, I (2) = 65.1%), but not for 606G>C (OR = 1.22, 95% CI = 0.75-1.96, P(heterogeneity )= 0.412, I (2) = 0.0%). Regarding 63A>G variant, positive results were also obtained in the subgroups of atrial septal defect and large-sample-size study. Besides, the sensitivity analysis indicated that significant association was still detected after deletion of the individual studies with positive result and striking heterogeneity. Our results revealed that the 63A>G variant in NKX2-5, but not the 606G>C, may contribute to CHD risk for Chinese.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0070979
PMID: 23936479
Source: Public Library of Science (PLoS) Journals Open Access
GFMER Free Medical Journals
MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Associations between two genetic variants in NKX2-5 and risk of congenital heart disease in Chinese population: a meta-analysis

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