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Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease

The New England journal of medicine, 2009-12, Vol.361 (26), p.2518-2528 [Peer Reviewed Journal]

Copyright © 2009 Massachusetts Medical Society. All rights reserved. ;2009 Massachusetts Medical Society ;ISSN: 0028-4793 ;ISSN: 1533-4406 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa0902604 ;PMID: 20032323 ;CODEN: NEJMAG

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Title:
Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease
Author: Clarke, Robert ; Peden, John F ; Hopewell, Jemma C ; Kyriakou, Theodosios ; Goel, Anuj ; Heath, Simon C ; Parish, Sarah ; Barlera, Simona ; Franzosi, Maria Grazia ; Rust, Stephan ; Bennett, Derrick ; Silveira, Angela ; Malarstig, Anders ; Green, Fiona R ; Lathrop, Mark ; Gigante, Bruna ; Leander, Karin ; de Faire, Ulf ; Seedorf, Udo ; Hamsten, Anders ; Collins, Rory ; Watkins, Hugh ; Farrall, Martin
Subjects: Apolipoproteins ; Cardiovascular disease ; Case-Control Studies ; Coronary Disease - blood ; Coronary Disease - genetics ; Coronary heart disease ; Coronary vessels ; Genes ; Genetic aspects ; Genetic Markers ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genotype ; Humans ; Kringles - genetics ; Likelihood Functions ; Lipoprotein A ; Lipoprotein(a) - blood ; Lipoprotein(a) - chemistry ; Lipoprotein(a) - genetics ; Lipoproteins ; Medicin och hälsovetenskap ; Myocardial Infarction - genetics ; Oligonucleotide Array Sequence Analysis ; Physiological aspects ; Polymorphism, Single Nucleotide ; Regression Analysis ; Risk Factors ; Systematic review
Is Part Of: The New England journal of medicine, 2009-12, Vol.361 (26), p.2518-2528
Description: Using a novel gene chip, investigators identified single-nucleotide polymorphisms (SNPs) from three chromosomal regions, including the LPA locus, that were associated with the risk of coronary disease. Two SNPs in LPA were strongly associated with both the level of Lp(a) lipoprotein and the risk of coronary disease. After adjustment for the Lp(a) lipoprotein level, the association with the risk of coronary disease was abolished. These findings support a causal role of an increased Lp(a) lipoprotein level in the risk of coronary disease. Two SNPs in the LPA locus were strongly associated with both the level of Lp(a) lipoprotein and the risk of coronary disease. These findings support a causal role of an increased Lp(a) lipoprotein level in the risk of coronary disease. Genomewide association studies have identified several novel susceptibility loci for coronary artery disease, 1 – 4 but it is likely that only common variants can be detected in this way. 5 , 6 Moreover, loci that are identified with the use of genomewide association studies explain only a small amount of the expected contribution to the risk of coronary disease. The use of arrays of high-density single-nucleotide polymorphisms (SNPs) in candidate genes for cardiovascular disease may help elucidate the genetic contribution to the risk of coronary disease. A recent genomewide association study showed that a cluster of genes — solute carrier family 22 member . . .
Publisher: United States: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
ISSN: 1533-4406
EISSN: 1533-4406
DOI: 10.1056/NEJMoa0902604
PMID: 20032323
CODEN: NEJMAG
Source: ProQuest One Psychology
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Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease

Copyright © 2009 Massachusetts Medical Society. All rights reserved. ;2009 Massachusetts Medical Society ;ISSN: 0028-4793 ;ISSN: 1533-4406 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa0902604 ;PMID: 20032323 ;CODEN: NEJMAG

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