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Genetic Associations with Valvular Calcification and Aortic Stenosis

The New England journal of medicine, 2013-02, Vol.368 (6), p.503-512 [Peer Reviewed Journal]

Copyright © 2013 Massachusetts Medical Society. All rights reserved. ;2014 INIST-CNRS ;Copyright © 2013 Massachusetts Medical Society. 2013 ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1109034 ;PMID: 23388002 ;CODEN: NEJMAG

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Title:
Genetic Associations with Valvular Calcification and Aortic Stenosis
Author: Thanassoulis, George ; Campbell, Catherine Y ; Owens, David S ; Smith, J. Gustav ; Smith, Albert V ; Peloso, Gina M ; Kerr, Kathleen F ; Pechlivanis, Sonali ; Budoff, Matthew J ; Harris, Tamara B ; Malhotra, Rajeev ; O'Brien, Kevin D ; Kamstrup, Pia R ; Nordestgaard, Børge G ; Tybjaerg-Hansen, Anne ; Allison, Matthew A ; Aspelund, Thor ; Criqui, Michael H ; Heckbert, Susan R ; Hwang, Shih-Jen ; Liu, Yongmei ; Sjogren, Marketa ; van der Pals, Jesper ; Kälsch, Hagen ; Mühleisen, Thomas W ; Nöthen, Markus M ; Cupples, L. Adrienne ; Caslake, Muriel ; Di Angelantonio, Emanuele ; Danesh, John ; Rotter, Jerome I ; Sigurdsson, Sigurdur ; Wong, Quenna ; Erbel, Raimund ; Kathiresan, Sekar ; Melander, Olle ; Gudnason, Vilmundur ; O'Donnell, Christopher J ; Post, Wendy S
Subjects: Aged ; Aortic Valve - diagnostic imaging ; Aortic Valve - pathology ; Aortic valve stenosis ; Aortic Valve Stenosis - diagnostic imaging ; Aortic Valve Stenosis - ethnology ; Aortic Valve Stenosis - genetics ; Atherosclerosis ; Biological and medical sciences ; Calcinosis - genetics ; Cardiac and Cardiovascular Systems ; Cardiology. Vascular system ; Cardiovascular disease ; Causes of ; Clinical Medicine ; Diseases ; Endocardial and cardiac valvular diseases ; Ethnic groups ; Family medical history ; Female ; General aspects ; Genetic aspects ; Genetic variation ; Genome-Wide Association Study ; Heart ; Heart Valve Diseases - diagnostic imaging ; Heart Valve Diseases - ethnology ; Heart Valve Diseases - genetics ; Humans ; Kardiologi ; Klinisk medicin ; Linear Models ; Lipoprotein(a) - genetics ; Male ; Medical and Health Sciences ; Medical imaging ; Medical sciences ; Medicin och hälsovetenskap ; Mendelian Randomization Analysis ; Middle Aged ; Mitral Valve - diagnostic imaging ; Mitral Valve - pathology ; Polymorphism, Single Nucleotide ; Tomography, X-Ray Computed ; Veins & arteries
Is Part Of: The New England journal of medicine, 2013-02, Vol.368 (6), p.503-512
Description: In a genomewide association study, a SNP in the LPA locus was significantly associated with aortic-valve calcification; this SNP was prospectively associated with incident aortic stenosis. Mendelian randomization suggested a causal role for lipoprotein(a) in aortic-valve calcification. Valvular calcification precedes the development of valvular stenosis and may represent an important early phenotype for valvular heart disease. Although aortic sclerosis is frequently considered to be a benign condition, it is associated with progression to clinical aortic stenosis 1 , 2 and with increased cardiovascular morbidity and mortality. 3 In addition, mitral annular calcification is associated with a risk of cardiovascular disease that is increased by nearly 50%. 4 Currently, there are no treatments that prevent or slow the progression of valve disease. Although genetic factors may influence the development of valvular calcification, which tends to run in families, 5 the role of common . . .
Publisher: Waltham, MA: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
EISSN: 1533-4406
DOI: 10.1056/NEJMoa1109034
PMID: 23388002
CODEN: NEJMAG
Source: ProQuest One Psychology
MEDLINE
Alma/SFX Local Collection
SWEPUB Freely available online
ProQuest Central

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Genetic Associations with Valvular Calcification and Aortic Stenosis

Copyright © 2013 Massachusetts Medical Society. All rights reserved. ;2014 INIST-CNRS ;Copyright © 2013 Massachusetts Medical Society. 2013 ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1109034 ;PMID: 23388002 ;CODEN: NEJMAG

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