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Oxidation of sulfonamide micropollutants by versatile peroxidase from Bjerkandera adusta

Revista internacional de contaminación ambiental, 2022-11, Vol.38, p.391-405 [Peer Reviewed Journal]

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. ;ISSN: 0188-4999 ;DOI: 10.20937/RICA.54390

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  • Title:
    Oxidation of sulfonamide micropollutants by versatile peroxidase from Bjerkandera adusta
  • Author: Bairán, Gabriela ; Chávez-Bravo, Edith ; Ortiz-Álvarez, Jossue ; Romero-Guido, Cynthia ; Torres, Eduardo
  • Subjects: Environmental Sciences
  • Is Part Of: Revista internacional de contaminación ambiental, 2022-11, Vol.38, p.391-405
  • Description: The oxidation of five sulfonamide antibiotics by the versatile peroxidase (VP, EC. 1.11.1.16) from Bjerkandera adusta was quantitatively assessed. The biocatalytic activity of the enzyme was studied by assaying different reaction conditions. Conversion levels were higher than 90 % for all five sulfonamide antibiotics in the model reaction system. In addition, the enzyme performance was also studied in treated wastewater effluents, where three sulfonamide antibiotics were oxidized at a higher level (greater than 85 % oxidation) and two were oxidized at a lower level (up to 50 %). The identified reaction products for two antibiotics, sulfasalazine, and sulfamethoxazole, showed higher antimicrobial activity than the parental compounds. Docking analyses exhibited that the reaction products interacted with the catalytic pocket of the dihydropteroate synthase from Escherichia coli, similar to the parental antibiotics. Though the oxidation is carried out at high velocity and conversion rates, the application of VP in the enzymatic oxidation technology of sulfonamide antibiotics must overcome the production of more toxic products.
  • Publisher: Universidad Nacional Autónoma de México, Centro de Ciencias de la Atmósfera
  • Language: English;Portuguese
  • Identifier: ISSN: 0188-4999
    DOI: 10.20937/RICA.54390
  • Source: SciELO
    Alma/SFX Local Collection
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