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Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences

European Respiratory Journal, 2021-05, Vol.57 (5), p.2003730 [Peer Reviewed Journal]

2021. This work is licensed under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Copyright ©The authors 2021 2021 ;ISSN: 0903-1936 ;EISSN: 1399-3003 ;DOI: 10.1183/13993003.03730-2020 ;PMID: 33479113

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  • Title:
    Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences
  • Author: Patel, Sheila K ; Juno, Jennifer A ; Lee, Wen Shi ; Wragg, Kathleen M ; Hogarth, P Mark ; Kent, Stephen J ; Burrell, Louise M
  • Subjects: Agora
  • Is Part Of: European Respiratory Journal, 2021-05, Vol.57 (5), p.2003730
  • Description: COVID-19 causes persistent endothelial inflammation, lung, cardiovascular, kidney and neurological complications as well as thromboembolic phenomena of unclear pathogenesis [1]. SARS-CoV-2 utilises the catalytic site of full-length membrane-bound angiotensin converting enzyme 2 (ACE2) for host cell entry [2], which is thought to downregulate membrane-bound ACE2, and thus contribute to ongoing inflammation due to loss of a degradative pathway for angiotensin II. In healthy individuals, ACE2 exists primarily in its membrane-bound form with very low levels of the catalytically active ectodomain of ACE2 present in the circulation [3]. However, in patients with cardiovascular disease, there is increased “shedding” of ACE2, and higher circulating levels are associated with downregulation of membrane-bound ACE2 [4].
  • Publisher: England: European Respiratory Society Journals Ltd
  • Language: English
  • Identifier: ISSN: 0903-1936
    EISSN: 1399-3003
    DOI: 10.1183/13993003.03730-2020
    PMID: 33479113
  • Source: Coronavirus Research Database
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