skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Seroprevalence of cytomegalovirus among pregnant women in Windhoek, Namibia, 2016

South African journal of obstetrics and gynaecology (1999), 2019-09, Vol.25 (2), p.xx-xx [Peer Reviewed Journal]

COPYRIGHT 2019 Health & Medical Publishing Group ;ISSN: 0038-2329 ;EISSN: 2078-5135 ;EISSN: 2305-8862 ;DOI: 10.7196/SAJOG.2019.v25i2.1441

Full text available

Citations Cited by
  • Title:
    Seroprevalence of cytomegalovirus among pregnant women in Windhoek, Namibia, 2016
  • Author: Mackenzie, S.B.P. ; Van der Colf, B.E. ; Van Zyl, G.U.
  • Subjects: Cytomegalovirus infections ; Developing countries ; Disease transmission ; Enzyme-linked immunosorbent assay ; Health aspects ; Immunoglobulin G ; Pregnancy ; Pregnant women
  • Is Part Of: South African journal of obstetrics and gynaecology (1999), 2019-09, Vol.25 (2), p.xx-xx
  • Description: Background. Seroprevalence of cytomegalovirus (CMV) is high in developing countries. However, a pregnant woman’s immunity does not necessarily protect her baby against congenital CMV infection.Objectives. To determine the seroprevalence of CMV among pregnant women attending a public antenatal clinic (Windhoek Central Hospital, Namibia) and subsequently determine the risk of vertical transmission and congenital CMV infection.Methods. Blood samples and demographic information were collected from 344 pregnant women (age range 15 - 48 years). Serum was tested for anti-CMV IgG and IgM using an automated chemiluminescence assay, and an ELISA was used to assess specific IgG avidity. Fisher’s exact test was used to determine associations among variables.Results. Seroprevalence of anti-CMV IgG was found to be 100% across the study population, with positive or grey-zone anti-CMV IgM results found in 11 women (3.2%). Specific IgG avidity was high in all cases. Neither maternal nor gestational age was positively associated with a positive or grey-zone IgM result. Parity was significantly associated with CMV IgM seroprevalence, with the highest level observed in women who had had one previous pregnancy.Conclusion. This was the first study to investigate seroprevalence of CMV in Namibia. Despite the high seroprevalence among pregnant women, the burden of congenital CMV infection may be carried by infants in the Namibian population. This may contribute to long-term disabilities, especially sensorineural hearing loss. Further studies are needed to determine the prevalence of congenital CMV in Namibia.
  • Publisher: Health and Medical Publishing Group (HMPG)
  • Language: English
  • Identifier: ISSN: 0038-2329
    EISSN: 2078-5135
    EISSN: 2305-8862
    DOI: 10.7196/SAJOG.2019.v25i2.1441
  • Source: Sabinet African Journals Open Access Collection
    African Journals Online (Open Access)
    GFMER Free Medical Journals
    Alma/SFX Local Collection
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait