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Mechanical dispersion as a marker of left ventricular dysfunction and prognosis in stable coronary artery disease

The International Journal of Cardiovascular Imaging, 2019-07, Vol.35 (7), p.1265-1275 [Peer Reviewed Journal]

Springer Nature B.V. 2019 ;The International Journal of Cardiovascular Imaging is a copyright of Springer, (2019). All Rights Reserved. ;info:eu-repo/semantics/openAccess ;ISSN: 1569-5794 ;EISSN: 1573-0743 ;EISSN: 1875-8312 ;DOI: 10.1007/s10554-019-01583-z ;PMID: 31165941

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Title:
Mechanical dispersion as a marker of left ventricular dysfunction and prognosis in stable coronary artery disease
Author: Kvisvik, Brede ; Aagaard, Erika Nerdrum ; Mørkrid, Lars ; Røsjø, Helge ; Lyngbakken, Magnus ; Smedsrud, Marit Kristine ; Eek, Christian ; Bendz, Bjørn ; Haugaa, Kristina H. ; Edvardsen, Thor ; Gravning, Jørgen
Subjects: Aged ; Biochemical markers ; Biomarkers - blood ; Brain natriuretic peptide ; Calcium-binding protein ; Cardiac Imaging ; Cardiology ; Cardiovascular disease ; Cause of Death ; Congestive heart failure ; Coronary artery ; Coronary artery disease ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - mortality ; Coronary Artery Disease - physiopathology ; Coronary Artery Disease - surgery ; Coronary vessels ; Dispersion ; Echocardiography ; Female ; Health risk assessment ; Heart ; Humans ; Imaging ; Male ; Markers ; Medicine ; Medicine & Public Health ; Middle Aged ; Mortality ; Myocardial infarction ; Myocardial Revascularization - adverse effects ; Myocardial Revascularization - mortality ; Natriuretic Peptide, Brain - blood ; Original Paper ; Patient Readmission ; Peptide Fragments - blood ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Radiology ; Risk Factors ; Serum levels ; Time Factors ; Treatment Outcome ; Troponin ; Troponin I ; Troponin I - blood ; Ventricle ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - mortality ; Ventricular Dysfunction, Left - physiopathology ; Ventricular Dysfunction, Left - therapy ; Ventricular Function, Left
Is Part Of: The International Journal of Cardiovascular Imaging, 2019-07, Vol.35 (7), p.1265-1275
Description: Assessment of global longitudinal strain (GLS) is superior to ejection fraction (EF) in the evaluation of left ventricular (LV) function in patients with stable coronary artery disease (CAD). However, the role of mechanical dispersion (MD) in this context remains unresolved. We aimed to evaluate the potential role of MD as a marker of LV dysfunction and long-term prognosis in stable CAD. EF, GLS and MD were assessed in 160 patients with stable CAD, 1 year after successful coronary revascularization. Serum levels of high-sensitivity cardiac troponin I (hs-cTnI) and amino-terminal pro B-type natriuretic peptide (NT-proBNP) were quantified as surrogate markers of LV dysfunction. The primary endpoint was defined as all-cause mortality, the secondary endpoint was defined as the composite of all-cause mortality and hospitalization for acute myocardial infarction or heart failure during follow-up. Whereas no associations between EF and the biochemical markers of LV function were found, both GLS and MD correlated positively with increasing levels of hs-cTnI (R = 0.315, P < 0.001 and R = 0.442, P < 0.001, respectively) and NT-proBNP (R = 0.195, P = 0.016 and R = 0.390, P < 0.001, respectively). Median MD was 46 ms (interquartile range [IQR] 37–53) and was successfully quantified in 96% of the patients. During a median follow-up of 8.4 (IQR 8.2–8.8) years, 14 deaths and 29 secondary events occurred. MD was significantly increased in non-survivors, and provided incremental prognostic value when added to EF and GLS. NT-proBNP was superior to the echocardiographic markers in predicting adverse outcomes. MD may be a promising marker of LV dysfunction and adverse prognosis in stable CAD.
Publisher: Dordrecht: Springer Netherlands
Language: English;Norwegian
Identifier: ISSN: 1569-5794
EISSN: 1573-0743
EISSN: 1875-8312
DOI: 10.1007/s10554-019-01583-z
PMID: 31165941
Source: MEDLINE
NORA Norwegian Open Research Archives
ProQuest Central

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Mechanical dispersion as a marker of left ventricular dysfunction and prognosis in stable coronary artery disease

Springer Nature B.V. 2019 ;The International Journal of Cardiovascular Imaging is a copyright of Springer, (2019). All Rights Reserved. ;info:eu-repo/semantics/openAccess ;ISSN: 1569-5794 ;EISSN: 1573-0743 ;EISSN: 1875-8312 ;DOI: 10.1007/s10554-019-01583-z ;PMID: 31165941

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