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1,5-anhydroglucitol is associated with early-phase insulin secretion in chinese patients with newly diagnosed type 2 diabetes mellitus

Diabetes technology & therapeutics, 2015-05, Vol.17 (5), p.320-326 [Peer Reviewed Journal]

ISSN: 1520-9156 ;EISSN: 1557-8593 ;DOI: 10.1089/dia.2014.0346 ;PMID: 25759909 ;CODEN: DTTHFH

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Title:
1,5-anhydroglucitol is associated with early-phase insulin secretion in chinese patients with newly diagnosed type 2 diabetes mellitus
Author: Ma, Xiaojing ; Hao, Yaping ; Hu, Xiang ; Luo, Yuqi ; Deng, Zixuan ; Zhou, Jian ; Bao, Yuqian ; Jia, Weiping
Subjects: Adult ; Aged ; Asian Continental Ancestry Group ; China ; Deoxyglucose - blood ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - ethnology ; Female ; Glucose ; Glycated Hemoglobin A - analysis ; Homeostasis ; Homeostasis - physiology ; Humans ; Insulin ; Insulin - blood ; Insulin - metabolism ; Insulin resistance ; Insulin Resistance - physiology ; Insulin Secretion ; Insulin-Secreting Cells - physiology ; Male ; Middle Aged ; Serum Albumin - analysis ; Trends
Is Part Of: Diabetes technology & therapeutics, 2015-05, Vol.17 (5), p.320-326
Description: The goal of the present study was to explore the correlations of 1,5-anhydroglucitol (l,5-AG), glycated hemoglobin (HbA1c), and glycated albumin (GA) with insulin sensitivity and secretion. In total, 302 patients with newly diagnosed type 2 diabetes mellitus (166 men, 136 women) were enrolled in this study. The homeostasis model assessment for insulin resistance (HOMA-IR) and homeostasis model assessment for β-cell function (HOMA-β) were calculated to determine the basal insulin sensitivity and secretion. The insulinogenic index (IGI) was used to evaluate early-phase insulin secretion. 1,5-AG and GA were assayed via the enzymatic method, and HbA1c was detected by high-pressure liquid chromatography. Among all 302 subjects, the serum 1,5-AG level was 13.1±7.2 μg/mL, and the HbA1c and GA levels [median (interquartile range)] were 6.7% (6.2-7.3%) and 17.7% (16.0-19.5%), respectively. Increased 1,5-AG quartiles were accompanied by trends toward a decreased HOMA-IR and an increased HOMA-β and IGI (for all trends, P<0.001). 1,5-AG was negatively associated with HOMA-IR (r=-0.200, P<0.001) and positively associated with HOMA-β and IGI (r=0.210 and 0.413, respectively; both P<0.001). 1,5-AG was independently related to HOMA-IR and HOMA-β and exhibited an independent positive association with IGI (standardized β=0.242, P<0.001). Additionally, both HbA1c and GA were independently correlated with HOMA-IR and HOMA-β. 1,5-AG is not only correlated with basal insulin sensitivity and secretion, but also closely associated with early-phase insulin secretion in Chinese patients with newly diagnosed type 2 diabetes mellitus.
Publisher: United States: Mary Ann Liebert, Inc
Language: English
Identifier: ISSN: 1520-9156
EISSN: 1557-8593
DOI: 10.1089/dia.2014.0346
PMID: 25759909
CODEN: DTTHFH
Source: MEDLINE
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1,5-anhydroglucitol is associated with early-phase insulin secretion in chinese patients with newly diagnosed type 2 diabetes mellitus

ISSN: 1520-9156 ;EISSN: 1557-8593 ;DOI: 10.1089/dia.2014.0346 ;PMID: 25759909 ;CODEN: DTTHFH

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