Language:

Association of Serum IL-6 (Interleukin 6) With Functional Outcome After Intracerebral Hemorrhage

Stroke (1970), 2021-05, Vol.52 (5), p.1733-1740 [Peer Reviewed Journal]

ISSN: 0039-2499 ;EISSN: 1524-4628 ;DOI: 10.1161/STROKEAHA.120.032888 ;PMID: 33682454

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Association of Serum IL-6 (Interleukin 6) With Functional Outcome After Intracerebral Hemorrhage
Author: Leasure, Audrey C ; Kuohn, Lindsey R ; Vanent, Kevin N ; Bevers, Matthew B ; Kimberly, W Taylor ; Steiner, Thorsten ; Mayer, Stephan A ; Matouk, Charles C ; Sansing, Lauren H ; Falcone, Guido J ; Sheth, Kevin N
Subjects: Aged ; Brain Edema - blood ; Brain Edema - drug therapy ; Brain Edema - etiology ; Brain Edema - pathology ; Cerebral Hemorrhage - blood ; Cerebral Hemorrhage - complications ; Cerebral Hemorrhage - drug therapy ; Cerebral Hemorrhage - pathology ; Double-Blind Method ; Factor VIIa - administration & dosage ; Female ; Humans ; Interleukin-6 - blood ; Male ; Middle Aged ; Patient Acuity ; Recombinant Proteins - administration & dosage
Is Part Of: Stroke (1970), 2021-05, Vol.52 (5), p.1733-1740
Description: IL-6 (interleukin 6) is a proinflammatory cytokine and an established biomarker in acute brain injury. We sought to determine whether admission IL-6 levels are associated with severity and functional outcome after spontaneous intracerebral hemorrhage (ICH). We performed an exploratory analysis of the recombinant activated FAST trial (Factor VII for Acute ICH). Patients with admission serum IL-6 levels were included. Regression analyses were used to assess the associations between IL-6 and 90-day modified Rankin Scale. In secondary analyses, we used linear regression to evaluate the association between IL-6 and baseline ICH and perihematomal edema volumes. Of 841 enrolled patients, we included 552 (66%) with available admission IL-6 levels (mean age 64 [SD 13], female sex 203 [37%]). IL-6 was associated with poor outcome (modified Rankin Scale, 4-6; per additional 1 ng/L, odds ratio, 1.30 [95% CI, 1.04-1.63]; =0.02) after adjustment for known predictors of outcome after ICH and treatment group. IL-6 was associated with ICH volume after adjustment for age, sex, and ICH location, and this association was modified by location (multivariable interaction, =0.002), with a stronger association seen in lobar (β, 12.51 [95% CI, 6.47-18.55], <0.001) versus nonlobar (β 5.32 [95% CI, 3.36-7.28], <0.001) location. IL-6 was associated with perihematomal edema volume after adjustment for age, sex, ICH volume, and ICH location (β 1.22 [95% CI, 0.15-2.29], =0.03). Treatment group was not associated with IL-6 levels or outcome. In the FAST trial population, higher admission IL-6 levels were associated with worse 90-day functional outcome and larger ICH and perihematomal edema volumes.
Publisher: United States
Language: English
Identifier: ISSN: 0039-2499
EISSN: 1524-4628
DOI: 10.1161/STROKEAHA.120.032888
PMID: 33682454
Source: MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Association of Serum IL-6 (Interleukin 6) With Functional Outcome After Intracerebral Hemorrhage

ISSN: 0039-2499 ;EISSN: 1524-4628 ;DOI: 10.1161/STROKEAHA.120.032888 ;PMID: 33682454

Searching Remote Databases, Please Wait