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Image analysis of retinal vasculature and retinal thickness for diagnosis of macular edema

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  • Title:
    Image analysis of retinal vasculature and retinal thickness for diagnosis of macular edema
  • Author: AJAZ, Aqsa
  • Subjects: Colour Fundus Photography ; Fluorescein Angiography ; Infrared Imaging ; Macular Edema ; Retina
  • Description: Traditionally, different imaging systems are available for diagnosis of Macular Edema (ME) such as Fundus Photography (FP), Slit Lamp biomicroscopy and Fluorescein Angiography (FA). However, FA is an invasive procedure and lacks information about retinal thickness, while FP requires a flash and is insensitive in detecting abnormalities in deeper layers of the retina. Recent technological advances have seen widespread use of Optical Coherence Tomography (OCT) which provides both cross-sectional and tomographic views of the retina. While OCT is considered the state-of-the-art, these are often not available in remote regions.  Further, currently the different image modalities are acquired by different equipment and there is the need for integrating these such as OCT and Infrared (IR) retinal imaging. This thesis has studied different imaging techniques like FP, FA OCT and IR retinal images with main focus on the key indicators such as damaged blood vessels and change in retinal thickness for diagnosis and monitoring of ME. This study has also investigated the relation between retinal vessel geometry features (RVGF) and retinal thickness in ME using different imaging systems. Another contribution of this thesis is that it has explored the utility of IR images of the retina for detecting the retinal morphological changes and other abnormalities related to ME diagnosis. The thesis has (i) Validated the application of IR fundus images recorded with the OCT using IR for investigating the superficial retinal vasculature and also validated that IR texture features may help clinicians in automatic detection of ME without further being investigated using other imaging systems. (ii) Investigated the association between OCT and FA parameters for Macular Edema detection and revealed that OCT measurements are suitable for objectively identifying the ME cases requiring clinical interventions. (iii) Investigated the association between retinal vessel geometrical features (RVGF) and the incidence and progression of Diabetic Macular Edema (DME) and suggested that Average Branching Angle can act as a potential biomarker indicative of progression of DME severity. Source: TROVE
  • Creation Date: 2020
  • Language: English
  • Source: Trove Australian Thesis (Full Text Open Access)
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