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Million Veteran Program: A mega-biobank to study genetic influences on health and disease

Journal of clinical epidemiology, 2016-02, Vol.70, p.214-223 [Peer Reviewed Journal]

2016 ;Published by Elsevier Inc. ;Copyright Elsevier Limited Feb 2016 ;ISSN: 0895-4356 ;EISSN: 1878-5921 ;DOI: 10.1016/j.jclinepi.2015.09.016 ;PMID: 26441289

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Title:
Million Veteran Program: A mega-biobank to study genetic influences on health and disease
Author: Gaziano, John Michael ; Concato, John ; Brophy, Mary ; Fiore, Louis ; Pyarajan, Saiju ; Breeling, James ; Whitbourne, Stacey ; Deen, Jennifer ; Shannon, Colleen ; Humphries, Donald ; Guarino, Peter ; Aslan, Mihaela ; Anderson, Daniel ; LaFleur, Rene ; Hammond, Timothy ; Schaa, Kendra ; Moser, Jennifer ; Huang, Grant ; Muralidhar, Sumitra ; Przygodzki, Ronald ; O'Leary, Timothy J
Subjects: Arthritis ; Biological Specimen Banks - organization & administration ; Biomedical research ; Cohort studies ; Consortia ; Data Collection - methods ; Electronic Health Records ; Exome sequencing ; Female ; Gastroesophageal reflux ; Genomes ; Genomics ; Genomics - methods ; Genotype ; Genotyping ; Health care delivery ; Humans ; Infrastructure ; Initiatives ; Internal Medicine ; Laboratories ; Longitudinal Studies ; Male ; Medical records ; Medical research ; Medicine ; Patients ; Population ; Research Design ; Sequence Analysis ; Studies ; Surveys and Questionnaires ; United States ; Veterans ; Veterans - statistics & numerical data ; Whole-genome sequencing
Is Part Of: Journal of clinical epidemiology, 2016-02, Vol.70, p.214-223
Description: Abstract Objective To describe the design and ongoing conduct of the Million Veteran Program (MVP), as an observational cohort study and mega-biobank in the Department of Veterans Affairs (VA) health care system. Study Design and Setting Data are being collected from participants using questionnaires, the VA electronic health record, and a blood sample for genomic and other testing. Several ongoing projects are linked to MVP, both as peer-reviewed research studies and as activities to help develop an infrastructure for future, broad-based research uses. Results Formal planning for MVP commenced in 2009; the protocol was approved in 2010, and enrollment began in 2011. As of August 3, 2015, and with a steady state of ≈50 recruiting sites nationwide, N = 397,104 veterans have been enrolled. Among N = 199,348 with currently available genotyping data, most participants (as expected) are male (92.0%) between the ages of 50 and 69 years (55.0%). On the basis of self-reported race, white (77.2%) and African American (13.5%) populations are well represented. Conclusions By helping to promote the future integration of genetic testing in health care delivery, including clinical decision making, the MVP is designed to contribute to the development of precision medicine.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0895-4356
EISSN: 1878-5921
DOI: 10.1016/j.jclinepi.2015.09.016
PMID: 26441289
Source: MEDLINE
ProQuest Central

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Million Veteran Program: A mega-biobank to study genetic influences on health and disease

2016 ;Published by Elsevier Inc. ;Copyright Elsevier Limited Feb 2016 ;ISSN: 0895-4356 ;EISSN: 1878-5921 ;DOI: 10.1016/j.jclinepi.2015.09.016 ;PMID: 26441289

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