Language:

Mechanisms of Functional Hypoconnectivity in the Medial Prefrontal Cortex of Mecp2 Null Mice

Cerebral cortex (New York, N.Y. 1991), 2016-05, Vol.26 (5), p.1938-1956 [Peer Reviewed Journal]

The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. ;The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com 2015 ;ISSN: 1047-3211 ;EISSN: 1460-2199 ;DOI: 10.1093/cercor/bhv002 ;PMID: 25662825

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Mechanisms of Functional Hypoconnectivity in the Medial Prefrontal Cortex of Mecp2 Null Mice
Author: Sceniak, Michael P ; Lang, Min ; Enomoto, Addison C ; James Howell, C ; Hermes, Douglas J ; Katz, David M
Subjects: Action Potentials ; Animals ; Calcium Signaling ; Dendritic Spines ; Electric Stimulation ; Excitatory Postsynaptic Potentials ; Inhibitory Postsynaptic Potentials ; Membrane Potentials ; Methyl-CpG-Binding Protein 2 - genetics ; Methyl-CpG-Binding Protein 2 - physiology ; Mice ; Mice, Knockout ; Nerve Tissue Proteins - metabolism ; Neurons - cytology ; Neurons - physiology ; Prefrontal Cortex - cytology ; Prefrontal Cortex - metabolism ; Prefrontal Cortex - physiology ; Receptors, AMPA - physiology ; Receptors, N-Methyl-D-Aspartate - metabolism ; Receptors, N-Methyl-D-Aspartate - physiology ; Respiration - genetics ; Rett Syndrome - genetics ; Rett Syndrome - physiopathology ; Vesicular Inhibitory Amino Acid Transport Proteins - metabolism
Is Part Of: Cerebral cortex (New York, N.Y. 1991), 2016-05, Vol.26 (5), p.1938-1956
Description: Frontal cortical dysfunction is thought to contribute to cognitive and behavioral features of autism spectrum disorders; however, underlying mechanisms are poorly understood. The present study sought to define how loss of Mecp2, the gene mutated in Rett syndrome (RTT), disrupts function in the murine medial prefrontal cortex (mPFC) using acute brain slices and behavioral testing. Compared with wildtype, pyramidal neurons in the Mecp2 null mPFC exhibit significant reductions in excitatory postsynaptic currents, the duration of excitatory UP-states, evoked population activity, and the ratio of NMDA:AMPA currents, as well as an increase in the relative fraction of NR2B currents. These functional changes are associated with reductions in the density of excitatory dendritic spines, the ratio of vesicular glutamate to GABA transporters and GluN1 expression. In contrast to recent reports on circuit defects in other brain regions, we observed no effect of Mecp2 loss on inhibitory synaptic currents or expression of the inhibitory marker parvalbumin. Consistent with mPFC hypofunction, Mecp2 nulls exhibit respiratory dysregulation in response to behavioral arousal. Our data highlight functional hypoconnectivity in the mPFC as a potential substrate for behavioral disruption in RTT and other disorders associated with reduced expression of Mecp2 in frontal cortical regions.
Publisher: United States: Oxford University Press
Language: English
Identifier: ISSN: 1047-3211
EISSN: 1460-2199
DOI: 10.1093/cercor/bhv002
PMID: 25662825
Source: MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Mechanisms of Functional Hypoconnectivity in the Medial Prefrontal Cortex of Mecp2 Null Mice

Searching Remote Databases, Please Wait