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Synthesis of Silver Nanoparticles Using a Novel Cyanobacteria Desertifilum sp. extract: Their Antibacterial and Cytotoxicity Effects

International journal of nanomedicine, 2020-01, Vol.15, p.49-63 [Peer Reviewed Journal]

2020 Hamida et al. ;COPYRIGHT 2020 Dove Medical Press Limited ;2020. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2020 Hamida et al. 2020 Hamida et al. ;ISSN: 1178-2013 ;ISSN: 1176-9114 ;EISSN: 1178-2013 ;DOI: 10.2147/IJN.S238575 ;PMID: 32021164

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Title:
Synthesis of Silver Nanoparticles Using a Novel Cyanobacteria Desertifilum sp. extract: Their Antibacterial and Cytotoxicity Effects
Author: Hamida, Reham Samir ; Abdelmeguid, Nabila Elsayed ; Ali, Mohamed Abdelaal ; Bin-Meferij, Mashael Mohammed ; Khalil, Mahmoud Ibrahim
Subjects: Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antineoplastic agents ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Bacteria ; Bacterial infections ; Caco-2 Cells ; Cancer ; Cancer cells ; Cancer research ; Cancer therapies ; Cancer treatment ; Cyanobacteria ; Cyanobacteria - chemistry ; Cyanobacteria - genetics ; Cyanobacteria - isolation & purification ; cytotoxic activity ; Cytotoxicity ; d-snps ; Deoxyribonucleic acid ; DNA ; Drug Evaluation, Preclinical ; Drug resistance ; E coli ; eco-friendly ; Genomes ; Gram-positive bacteria ; Health aspects ; Hep G2 Cells ; Humans ; Infection ; MCF-7 Cells ; Metal Nanoparticles - chemistry ; Microbial Sensitivity Tests ; Morphology ; Nanoparticles ; Nanotechnology ; Novels ; Original Research ; Phylogenetics ; physicochemical ; Plant Extracts - chemistry ; Polymerase chain reaction ; Polysaccharides ; Proteins ; Silver ; Silver - chemistry ; Silver nitrate ; Silver Nitrate - chemistry ; Spectroscopy, Fourier Transform Infrared ; Surface Plasmon Resonance ; Time ; Toxicity
Is Part Of: International journal of nanomedicine, 2020-01, Vol.15, p.49-63
Description: The emergence of multi drug-resistant (MDR) bacterial infections and cancer has necessitated the development and discovery of alternative eco-safe antibacterial and anticancer agents. Biogenic fabrication of metallic nanoparticles is an emerging discipline for production of nanoproducts that exert potent anticancer and antibacterial activity, and do not suffer from the limitations inherent in physiochemical synthesis methods. In this study, we isolated, purified, and characterized a novel cyanobacteria extract ( IPPAS B-1220) to utilize in biofabrication of silver nanoparticles (D-SNPs). D-SNPs were produced by adding extract to silver nitrate solution under controlled conditions. Biofabrication of D-SNPs was confirmed using a UV-Vis spectrophotometer. The resultant D-SNPs were characterized using XRD, FTIR, SEM, and TEM. The toxicity of D-SNPs against five pathogenic bacteria and three cancer cell lines (MCF-7, HepG2, and Caco-2) was evaluated. Formation of D-SNPs was indicated by a color change from pale yellow to dark brown. The peak of the surface plasmon resonance of the D-SNPs was at 421 nm. The XRD detected the crystallinity of D-SNPs. FTIR showed that polysaccharides and proteins may have contributed to the biofabrication of D-SNPs. Under SEM and TEM, the D-SNPs were spherical with diameter ranges from 4.5 to 26 nm. The D-SNPs significantly suppressed the growth of five pathogenic bacteria, and exerted cytotoxic effects against MCF-7, HepG2, and Caco-2 cancer cells with IC values of 58, 32, and 90 µg/mL, respectively. These findings showed for the first time the potentiality of novel cyanobacteria strain IPPAS B-1220 to fabricate small SNPs that acted as potent anticancer and antibacterial material against different cancer cell lines and pathogenic bacterial strains. These findings encourage the researchers to focus on cyanobacteria in general and especially sp. IPPAS B-1220 for synthesizing different NPs that opening the window for new applications.
Publisher: New Zealand: Dove Medical Press Limited
Language: English
Identifier: ISSN: 1178-2013
ISSN: 1176-9114
EISSN: 1178-2013
DOI: 10.2147/IJN.S238575
PMID: 32021164
Source: TestCollectionTL3OpenAccess
GFMER Free Medical Journals
MEDLINE
PubMed Central
DOVE Medical Press Journals
ProQuest Central

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Synthesis of Silver Nanoparticles Using a Novel Cyanobacteria Desertifilum sp. extract: Their Antibacterial and Cytotoxicity Effects

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