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Novel nanomaterial-based antibacterial photodynamic therapies to combat oral bacterial biofilms and infectious diseases

International journal of nanomedicine, 2019-01, Vol.14, p.6937-6956 [Peer Reviewed Journal]

2019 Qi et al. ;COPYRIGHT 2019 Dove Medical Press Limited ;2019 Qi et al. 2019 Qi et al. ;ISSN: 1178-2013 ;ISSN: 1176-9114 ;EISSN: 1178-2013 ;DOI: 10.2147/ijn.s212807 ;PMID: 31695368

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Title:
Novel nanomaterial-based antibacterial photodynamic therapies to combat oral bacterial biofilms and infectious diseases
Author: Qi, Manlin ; Chi, Minghan ; Sun, Xiaolin ; Xie, Xianju ; Weir, Michael D ; Oates, Thomas W ; Zhou, Yanmin ; Wang, Lin ; Bai, Yuxing ; Xu, Hockin Hk
Subjects: Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; anti-inflammatory ; antibacterial ; Antibacterial agents ; Bacteria ; Bacterial Infections - drug therapy ; Biofilms - drug effects ; Care and treatment ; Communicable diseases ; Health aspects ; Humans ; Infection ; Microorganisms ; Mouth - microbiology ; nanomaterials ; Nanoparticles ; Nanostructures - chemistry ; Nanotechnology ; Novels ; oral diseases ; Periodontal diseases ; Photochemotherapy ; photodynamic therapy ; Review ; Tissue engineering ; Toxicity ; upconversion nanoparticles
Is Part Of: International journal of nanomedicine, 2019-01, Vol.14, p.6937-6956
Description: Oral diseases such as tooth caries, periodontal diseases, endodontic infections, etc., are prevalent worldwide. The heavy burden of oral infectious diseases and their consequences on the patients' quality of life indicates a strong need for developing effective therapies. Advanced understandings of such oral diseases, e.g., inflammatory periodontal lesions, have raised the demand for antibacterial therapeutic strategies, because these diseases are caused by viruses and bacteria. The application of antimicrobial photodynamic therapy (aPDT) on oral infectious diseases has attracted tremendous interest in the past decade. However, aPDT had a minimal effect on the viability of organized biofilms due to the hydrophobic nature of the majority of the photosensitizers (PSs). Therefore, novel nanotechnologies were rapidly developed to target the delivery of hydrophobic PSs into microorganisms for the antimicrobial performance improvement of aPDT. This review focuses on the state-of-the-art of nanomaterials applications in aPDT against oral infectious diseases. The first part of this article focuses on the cutting-edge research on the synthesis, toxicity, and therapeutic effects of various forms of nanomaterials serving as PS carriers for aPDT applications. The second part discusses nanomaterials applications for aPDT in treatments of oral diseases. These novel bioactive nanomaterials have demonstrated great potential to serve as carriers for PSs to substantially enhance the PDT therapeutic effects. Furthermore, the novel aPDT applications not only have exciting therapeutic potential to inhibit bacterial plaque-initiated oral diseases, but also have a wide applicability to other biomedical and tissue engineering applications.
Publisher: New Zealand: Dove Medical Press Limited
Language: English
Identifier: ISSN: 1178-2013
ISSN: 1176-9114
EISSN: 1178-2013
DOI: 10.2147/ijn.s212807
PMID: 31695368
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
DOVE Medical Press Journals
ProQuest Central
DOAJ Directory of Open Access Journals

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Novel nanomaterial-based antibacterial photodynamic therapies to combat oral bacterial biofilms and infectious diseases

2019 Qi et al. ;COPYRIGHT 2019 Dove Medical Press Limited ;2019 Qi et al. 2019 Qi et al. ;ISSN: 1178-2013 ;ISSN: 1176-9114 ;EISSN: 1178-2013 ;DOI: 10.2147/ijn.s212807 ;PMID: 31695368

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