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Biological and clinical insights from genetics of insomnia symptoms

Nature genetics, 2019-03, Vol.51 (3), p.387-393 [Peer Reviewed Journal]

Copyright Nature Publishing Group Mar 2019 ;info:eu-repo/semantics/openAccess ;ISSN: 1061-4036 ;ISSN: 1546-1718 ;EISSN: 1546-1718 ;DOI: 10.1038/s41588-019-0361-7 ;PMID: 30804566

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Title:
Biological and clinical insights from genetics of insomnia symptoms
Author: Lane, Jacqueline M ; Jones, Samuel E ; Dashti, Hassan S ; Wood, Andrew R ; Aragam, Krishna G ; van Hees, Vincent T ; Strand, Linn B ; Winsvold, Bendik S ; Wang, Heming ; Bowden, Jack ; Song, Yanwei ; Patel, Krunal ; Anderson, Simon G ; Beaumont, Robin N ; Bechtold, David A ; Cade, Brian E ; Haas, Mary ; Kathiresan, Sekar ; Little, Max A ; Luik, Annemarie I ; Loudon, Andrew S ; Purcell, Shaun ; Richmond, Rebecca C ; Scheer, Frank A J L ; Schormair, Barbara ; Tyrrell, Jessica ; Winkelman, John W ; Winkelmann, Juliane ; Hveem, Kristian ; Zhao, Chen ; Nielsen, Jonas B ; Willer, Cristen J ; Redline, Susan ; Spiegelhalder, Kai ; Kyle, Simon D ; Ray, David W ; Zwart, John-Anker ; Brumpton, Ben ; Frayling, Timothy M ; Lawlor, Deborah A ; Rutter, Martin K ; Weedon, Michael N ; Saxena, Richa
Subjects: Accelerometers ; Adrenal glands ; Adult ; Aged ; Aging ; Bias ; Bioinformatics ; Brain ; Cardiovascular disease ; Case-Control Studies ; Coronary artery ; Coronary artery disease ; Female ; Gene Expression - genetics ; Gene loci ; Genes ; Genetic factors ; Genetic Predisposition to Disease - genetics ; Genetics ; Genomes ; Genomics ; Heart diseases ; Humans ; Insomnia ; Male ; Medicin och hälsovetenskap ; Mental depression ; Middle Aged ; Muscles ; Population ; Proteolysis ; Psychological factors ; Restless legs syndrome ; Self Report ; Signs and symptoms ; Skeletal muscle ; Sleep ; Sleep - genetics ; Sleep disorders ; Sleep Initiation and Maintenance Disorders - genetics ; Studies ; Ubiquitin ; Ubiquitin - genetics ; Womens health
Is Part Of: Nature genetics, 2019-03, Vol.51 (3), p.387-393
Description: Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we identified 57 loci for self-reported insomnia symptoms in the UK Biobank (n = 453,379) and confirmed their effects on self-reported insomnia symptoms in the HUNT Study (n = 14,923 cases and 47,610 controls), physician-diagnosed insomnia in the Partners Biobank (n = 2,217 cases and 14,240 controls), and accelerometer-derived measures of sleep efficiency and sleep duration in the UK Biobank (n = 83,726). Our results suggest enrichment of genes involved in ubiquitin-mediated proteolysis and of genes expressed in multiple brain regions, skeletal muscle, and adrenal glands. Evidence of shared genetic factors was found between frequent insomnia symptoms and restless legs syndrome, aging, and cardiometabolic, behavioral, psychiatric, and reproductive traits. Evidence was found for a possible causal link between insomnia symptoms and coronary artery disease, depressive symptoms, and subjective well-being.
Publisher: United States: Nature Publishing Group
Language: English;Norwegian
Identifier: ISSN: 1061-4036
ISSN: 1546-1718
EISSN: 1546-1718
DOI: 10.1038/s41588-019-0361-7
PMID: 30804566
Source: Geneva Foundation Free Medical Journals at publisher websites
AUTh Library subscriptions: ProQuest Central
MEDLINE
NORA Norwegian Open Research Archives
SWEPUB Freely available online

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Biological and clinical insights from genetics of insomnia symptoms

Copyright Nature Publishing Group Mar 2019 ;info:eu-repo/semantics/openAccess ;ISSN: 1061-4036 ;ISSN: 1546-1718 ;EISSN: 1546-1718 ;DOI: 10.1038/s41588-019-0361-7 ;PMID: 30804566

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