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Respiratory symptoms and cardiovascular causes of deaths: A population-based study with 45 years of follow-up

PloS one, 2022-10, Vol.17 (10), p.e0276560-e0276560 [Peer Reviewed Journal]

COPYRIGHT 2022 Public Library of Science ;2022 Stavem et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;info:eu-repo/semantics/openAccess ;2022 Stavem et al 2022 Stavem et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0276560

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Title:
Respiratory symptoms and cardiovascular causes of deaths: A population-based study with 45 years of follow-up
Author: Stavem, Knut ; Schirmer, Henrik ; Gulsvik, Amund
Torén, Kjell
Subjects: Air pollution ; Analysis ; Angina pectoris ; Biology and Life Sciences ; Blood circulation disorders ; Bronchitis ; Cardiovascular disease ; Cardiovascular diseases ; Care and treatment ; Cerebrovascular diseases ; Chronic obstructive pulmonary disease ; Confidence intervals ; Consent ; Coronary artery disease ; Cough ; Death ; Diagnosis ; Education ; Emigration ; Environmental aspects ; Fatalities ; Health aspects ; Health risks ; Heart ; Heart attacks ; Heart diseases ; Ischemia ; Medical research ; Medicine and Health Sciences ; Mortality ; Myocardial infarction ; People and places ; Personal identification numbers ; Polls & surveys ; Population studies ; Population-based studies ; Pulmonary manifestations of general diseases ; Questionnaires ; Questions ; Regression analysis ; Research ethics ; Risk factors ; Signs and symptoms ; Smoking ; Statistical analysis ; Tuberculosis ; Vascular diseases ; Wheezing
Is Part Of: PloS one, 2022-10, Vol.17 (10), p.e0276560-e0276560
Description: This study determined the association between respiratory symptoms and death from cardiovascular (CV) diseases during 45 years in a pooled sample of four cohorts of random samples of the Norwegian population with 95,704 participants. Respiratory symptoms were assessed using a modification of the MRC questionnaire on chronic bronchitis. We analyzed the association between respiratory symptoms and specific cardiovascular deaths by using Cox regression analysis with age as the time variable, accounting for cluster-specific random effects using shared frailty for study cohort. Hazard ratios (HR) for death were adjusted for sex, highest attained education, smoking habits, occupational air pollution, and birth cohort. Overall, 12,491 (13%) of participants died from CV diseases: 4,123 (33%) acute myocardial infarction, 2,326 (18%) other ischemic heart disease, 2,246 (18%) other heart diseases, 2,553 (20%) cerebrovascular diseases, and 1,120 (9%) other vascular diseases. The adjusted HR (95% confidence interval) for CV deaths was 1.9 (1.7–2.1) in men and 1.5 (1.2–1.9) in women for “yes” to the question “Are you breathless when you walk on level ground at an ordinary pace?”. The same item response showed an adjusted HR for death from acute myocardial infarction of 1.8 (1.5–2.1), other ischemic heart disease 2.2 (1.8–2.7), other heart diseases 1.5 (1.1–1.9), cerebrovascular disease 1.8 (1.5–2.3), and other circulatory diseases 1.7 (1.2–2.4). The adjusted HR for CV death was 1.3 (1.2–1.4) when answering positive to the question” Are you more breathless than people of your own age when walking uphill?”. However, positive answers to questions on cough, phlegm, wheezing and attacks of breathlessness were after adjustments not associated with early CV deaths. The associations between CV deaths and breathlessness were also present in never smokers. Self-reported breathlessness was associated with CV deaths and could be an early marker of CV deaths.
Publisher: San Francisco: Public Library of Science
Language: English;Norwegian
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0276560
Source: AUTh Library subscriptions: ProQuest Central
GFMER Free Medical Journals
NORA Norwegian Open Research Archives
PubMed Central
Public Library of Science
Coronavirus Research Database
DOAJ Directory of Open Access Journals

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Respiratory symptoms and cardiovascular causes of deaths: A population-based study with 45 years of follow-up

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