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Association of coincident self-reported mental health problems and alcohol intake with all-cause and cardiovascular disease mortality: A Norwegian pooled population analysis

PLoS medicine, 2020-02, Vol.17 (2), p.e1003030-e1003030 [Peer Reviewed Journal]

2020 Degerud et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;info:eu-repo/semantics/openAccess ;2020 Degerud et al 2020 Degerud et al ;ISSN: 1549-1676 ;ISSN: 1549-1277 ;EISSN: 1549-1676 ;DOI: 10.1371/JOURNAL.PMED.1003030 ;PMID: 32012170

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  • Title:
    Association of coincident self-reported mental health problems and alcohol intake with all-cause and cardiovascular disease mortality: A Norwegian pooled population analysis
  • Author: Degerud, Eirik ; Høiseth, Gudrun ; Mørland, Jørg ; Ariansen, Inger ; Graff-Iversen, Sidsel ; Ystrom, Eivind ; Zuccolo, Luisa ; Næss, Øyvind
  • Hanlon, Charlotte
  • Subjects: Adult ; Age ; Alcohol Drinking - epidemiology ; Alcohol use ; Biology and Life Sciences ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - mortality ; Cause of Death ; Clinical medicine ; Comorbidity ; Drinking behavior ; Epidemiology ; Exercise ; Female ; Health Surveys ; Hospitals ; Humans ; Male ; Medicine and Health Sciences ; Mental disorders ; Mental Disorders - epidemiology ; Mental health ; Middle Aged ; Mortality ; Norway - epidemiology ; People and Places ; Personal identification numbers ; Population ; Population studies ; Proportional Hazards Models ; Public health ; Research and Analysis Methods ; Risk factors ; Self Report
  • Is Part Of: PLoS medicine, 2020-02, Vol.17 (2), p.e1003030-e1003030
  • Description: The disease burden attributable to mental health problems and to excess or harmful alcohol use is considerable. Despite a strong relationship between these 2 important factors in population health, there are few studies quantifying the mortality risk associated with their co-occurrence in the general population. The aim of this study was therefore to investigate cardiovascular disease (CVD) and all-cause mortality according to self-reported mental health problems and alcohol intake in the general population. We followed 243,372 participants in Norwegian health surveys (1994-2002) through 2014 for all-cause and CVD mortality by data linkage to national registries. The mean (SD) age at the time of participation in the survey was 43.9 (10.6) years, and 47.8% were men. During a mean (SD) follow-up period of 16.7 (3.2) years, 6,587 participants died from CVD, and 21,376 died from all causes. Cox models estimated hazard ratios (HRs) with 95% CIs according to a mental health index (low, 1.00-1.50; high, 2.01-4.00; low score is favourable) based on the General Health Questionnaire and the Hopkins Symptom Checklist, and according to self-reported alcohol intake (low, <2; light, 2-11.99; moderate, 12-23.99; high, ≥24 grams/day). HRs were adjusted for age, sex, educational level, marital status, and CVD risk factors. Compared to a reference group with low mental health index score and low alcohol intake, HRs (95% CIs) for all-cause mortality were 0.93 (0.89, 0.97; p = 0.001), 1.00 (0.92, 1.09; p = 0.926), and 1.14 (0.96, 1.35; p = 0.119) for low index score combined with light, moderate, and high alcohol intake, respectively. HRs (95% CIs) were 1.22 (1.14, 1.31; p < 0.001), 1.24 (1.15, 1.33; p < 0.001), 1.43 (1.23, 1.66; p < 0.001), and 2.29 (1.87, 2.80; p < 0.001) for high index score combined with low, light, moderate, and high alcohol intake, respectively. For CVD mortality, HRs (95% CIs) were 0.93 (0.86, 1.00; p = 0.058), 0.90 (0.76, 1.07; p = 0.225), and 0.95 (0.67, 1.33; p = 0.760) for a low index score combined with light, moderate, and high alcohol intake, respectively, and 1.11 (0.98, 1.25; p = 0.102), 0.97 (0.83, 1.13; p = 0.689), 1.01 (0.71, 1.44; p = 0.956), and 1.78 (1.14, 2.78; p = 0.011) for high index score combined with low, light, moderate, and high alcohol intake, respectively. HRs for the combination of a high index score and high alcohol intake (HRs: 2.29 for all-cause and 1.78 for CVD mortality) were 64% (95% CI 53%, 74%; p < 0.001) and 69% (95% CI 42%, 97%; p < 0.001) higher than expected for all-cause mortality and CVD mortality, respectively, under the assumption of a multiplicative interaction structure. A limitation of our study is that the findings were based on average reported intake of alcohol without accounting for the drinking pattern. In the general population, the mortality rates associated with more mental health problems and a high alcohol intake were increased when the risk factors occurred together.
  • Publisher: United States: Public Library of Science
  • Language: English;Norwegian
  • Identifier: ISSN: 1549-1676
    ISSN: 1549-1277
    EISSN: 1549-1676
    DOI: 10.1371/JOURNAL.PMED.1003030
    PMID: 32012170
  • Source: GFMER Free Medical Journals
    MEDLINE
    NORA Norwegian Open Research Archives
    PubMed Central
    Public Library of Science (PLoS)
    ProQuest Central
    DOAJ Directory of Open Access Journals

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