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Cardiac Troponin I and T Are Associated with Left Ventricular Function and Structure: Data from the Akershus Cardiac Examination 1950 Study

Clinical chemistry (Baltimore, Md.), 2020-04, Vol.66 (4), p.567-578 [Peer Reviewed Journal]

American Association for Clinical Chemistry 2020. 2020 ;American Association for Clinical Chemistry 2020. All rights reserved. For permissions, please email: journals.permissions@oup.com. ;COPYRIGHT 2020 American Association for Clinical Chemistry, Inc. ;American Association for Clinical Chemistry 2020. ;info:eu-repo/semantics/openAccess ;ISSN: 0009-9147 ;EISSN: 1530-8561 ;DOI: 10.1093/clinchem/hvaa023 ;PMID: 32227098

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  • Title:
    Cardiac Troponin I and T Are Associated with Left Ventricular Function and Structure: Data from the Akershus Cardiac Examination 1950 Study
  • Author: Lyngbakken, Magnus Nakrem ; Aagaard, Erika Nerdrum ; Kvisvik, Brede ; Berge, Trygve ; Pervez, Mohammad Osman ; Brynildsen, Jon ; Tveit, Arnljot ; Steine, Kjetil ; Røsjø, Helge ; Omland, Torbjørn
  • Subjects: Calcium-binding protein ; Cardiovascular diseases ; Echocardiography ; Education ; Ethylenediaminetetraacetic acid ; Health risks ; Hypertension ; Hypertrophy ; Men ; Phenotypes ; Phenotyping ; Risk analysis ; Risk factors ; Structure-function relationships ; Troponin ; Troponin I ; Ventricle
  • Is Part Of: Clinical chemistry (Baltimore, Md.), 2020-04, Vol.66 (4), p.567-578
  • Description: Abstract Background Concentrations of cardiac troponin I (cTnI) and T (cTnT) are associated with clinical cardiac outcomes, but do not correlate closely in subjects recruited from the general population. Accordingly, we hypothesized that cTnI and cTnT concentrations would be influenced by different cardiovascular (CV) and non-CV risk factors and reflect different CV phenotypes. Methods We measured cTnI and cTnT with last generation assays in 1236 women and 1157 men with no known CV disease participating in the prospective observational Akershus Cardiac Examination 1950 Study. All study participants underwent extensive CV phenotyping at baseline, including detailed echocardiography. Results Concentrations of cTnI were measurable in 60.3% and cTnT in 72.5% of study participants (P < 0.001), and correlated moderately (r = 0.53; P < 0.001). cTnI was more strongly associated with male sex (P = 0.018), higher education (P < 0.001), history of hypertension (P < 0.001), and age (P < 0.001), whereas cTnT was more strongly associated with eGFR (P = 0.015). Both cTnI and cTnT were inversely associated with global longitudinal strain and positively associated with LV mass index (LVMI) in analyses adjusted for CV risk factors. The association between cTnI and LVMI was stronger than the association between cTnT and LVMI (P = 0.035). Concentrations of cTnI improved diagnostic accuracy for LV hypertrophy when added to established CV risk factors, but concentrations of cTnT did not improve these models further. Conclusions In a large community-based cohort examined with extensive echocardiography, concentrations of cTnI and cTnT are associated with subclinical LV hypertrophy and dysfunction. Concentrations of cTnI appear superior to cTnT in predicting subclinical LV hypertrophy.
  • Publisher: England: Oxford University Press
  • Language: English;Norwegian
  • Identifier: ISSN: 0009-9147
    EISSN: 1530-8561
    DOI: 10.1093/clinchem/hvaa023
    PMID: 32227098
  • Source: Oxford Journals Open Access Collection
    NORA Norwegian Open Research Archives
    ProQuest Central
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