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A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms

Psychopharmacology, 2019-09, Vol.236 (9), p.2653-2666 [Peer Reviewed Journal]

The Author(s) 2019 ;COPYRIGHT 2019 Springer ;Psychopharmacology is a copyright of Springer, (2019). All Rights Reserved. © 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 0033-3158 ;EISSN: 1432-2072 ;DOI: 10.1007/s00213-019-05236-w ;PMID: 30982127

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  • Title:
    A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms
  • Author: Uthaug, M. V. ; Lancelotta, R. ; van Oorsouw, K. ; Kuypers, K. P. C. ; Mason, N. ; Rak, J. ; Šuláková, A. ; Jurok, R. ; Maryška, M. ; Kuchař, M. ; Páleníček, T. ; Riba, J. ; Ramaekers, J. G.
  • Subjects: Anxiety ; Biomedical and Life Sciences ; Biomedicine ; Care and treatment ; Cognition ; Depression, Mental ; Exploration ; Glands ; Health aspects ; Health problems ; Inhalation ; Long-term effects ; Mental disorders ; Mental health ; Mindfulness ; Neurosciences ; Original Investigation ; Pharmacology/Toxicology ; Psychiatry ; Ratings ; Ratings & rankings ; Respiration ; Secretion ; Therapeutic applications ; Vapors
  • Is Part Of: Psychopharmacology, 2019-09, Vol.236 (9), p.2653-2666
  • Description: Background 5-methoxy-N,N-dimethyltryptamine (hereinafter referred to as 5-MeO-DMT) is a psychedelic substance found in the secretion from the parotoid glands of the Bufo alvarius toad. Inhalation of vapor from toad secretion containing 5-MeO-DMT has become popular in naturalistic settings as a treatment of mental health problems or as a means for spiritual exploration. However, knowledge of the effects of 5-MeO-DMT in humans is limited. Aims The first objective of this study was to assess sub-acute and long-term effects of inhaling vapor from dried toad secretion containing 5-MeO-DMT on affect and cognition. The second objective was to assess whether any changes were associated with the psychedelic experience. Methods Assessments at baseline, within 24 h and 4 weeks following intake, were made in 42 individuals who inhaled vapor from dried toad secretion at several European locations. Results Relative to baseline, ratings of satisfaction with life and convergent thinking significantly increased right after intake and were maintained at follow-up 4 weeks later. Ratings of mindfulness also increased over time and reached statistical significance at 4 weeks. Ratings of depression, anxiety, and stress decreased after the session, and reached significance at 4 weeks. Participants that experienced high levels of ego dissolution or oceanic boundlessness during the session displayed higher ratings of satisfaction with life and lower ratings of depression and stress. Conclusion A single inhalation of vapor from dried toad secretion containing 5-MeO-DMT produces sub-acute and long-term changes in affect and cognition in volunteers. These results warrant exploratory research into therapeutic applications of 5-MeO-DMT.
  • Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
  • Language: English
  • Identifier: ISSN: 0033-3158
    EISSN: 1432-2072
    DOI: 10.1007/s00213-019-05236-w
    PMID: 30982127
  • Source: ProQuest One Psychology
    Springer Nature OA/Free Journals
    ProQuest Central
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