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Single-Cell Analysis in the IOmics/I Era: Technologies and Applications in Cancer

Genes, 2023-06, Vol.14 (7) [Peer Reviewed Journal]

COPYRIGHT 2023 MDPI AG ;ISSN: 2073-4425 ;EISSN: 2073-4425 ;DOI: 10.3390/genes14071330

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  • Title:
    Single-Cell Analysis in the IOmics/I Era: Technologies and Applications in Cancer
  • Author: Massimino, Michele ; Martorana, Federica ; Stella, Stefania ; Vitale, Silvia Rita ; Tomarchio, Cristina ; Manzella, Livia ; Vigneri, Paolo
  • Subjects: Cancer ; Development and progression
  • Is Part Of: Genes, 2023-06, Vol.14 (7)
  • Description: Cancer molecular profiling obtained with conventional bulk sequencing describes average alterations obtained from the entire cellular population analyzed. In the era of precision medicine, this approach is unable to track tumor heterogeneity and cannot be exploited to unravel the biological processes behind clonal evolution. In the last few years, functional single-cell omics has improved our understanding of cancer heterogeneity. This approach requires isolation and identification of single cells starting from an entire population. A cell suspension obtained by tumor tissue dissociation or hematological material can be manipulated using different techniques to separate individual cells, employed for single-cell downstream analysis. Single-cell data can then be used to analyze cell–cell diversity, thus mapping evolving cancer biological processes. Despite its unquestionable advantages, single-cell analysis produces massive amounts of data with several potential biases, stemming from cell manipulation and pre-amplification steps. To overcome these limitations, several bioinformatic approaches have been developed and explored. In this work, we provide an overview of this entire process while discussing the most recent advances in the field of functional omics at single-cell resolution.
  • Publisher: MDPI AG
  • Language: English
  • Identifier: ISSN: 2073-4425
    EISSN: 2073-4425
    DOI: 10.3390/genes14071330
  • Source: PubMed Central
    Directory of Open Access Journals
    ROAD: Directory of Open Access Scholarly Resources
    ProQuest Central
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