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Single-cell reconstruction of the early maternal-fetal interface in humans

Nature (London), 2018-11, Vol.563 (7731), p.347-353 [Peer Reviewed Journal]

COPYRIGHT 2018 Nature Publishing Group ;COPYRIGHT 2018 Nature Publishing Group ;Copyright Nature Publishing Group Nov 15, 2018 ;ISSN: 0028-0836 ;ISSN: 1476-4687 ;EISSN: 1476-4687 ;DOI: 10.1038/s41586-018-0698-6 ;PMID: 30429548

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Title:
Single-cell reconstruction of the early maternal-fetal interface in humans
Author: Vento-Tormo, Roser ; Efremova, Mirjana ; Botting, Rachel A ; Turco, Margherita Y ; Vento-Tormo, Miquel ; Meyer, Kerstin B ; Park, Jong-Eun ; Stephenson, Emily ; Polański, Krzysztof ; Goncalves, Angela ; Gardner, Lucy ; Holmqvist, Staffan ; Henriksson, Johan ; Zou, Angela ; Sharkey, Andrew M ; Millar, Ben ; Innes, Barbara ; Wood, Laura ; Wilbrey-Clark, Anna ; Payne, Rebecca P ; Ivarsson, Martin A ; Lisgo, Steve ; Filby, Andrew ; Rowitch, David H ; Bulmer, Judith N ; Wright, Gavin J ; Stubbington, Michael J T ; Haniffa, Muzlifah ; Moffett, Ashley ; Teichmann, Sarah A
Subjects: Adaptive immunity ; Animal reproduction ; Bioinformatics ; Breeding success ; Cell Communication - immunology ; Cell Differentiation - genetics ; Cell interaction ; Cell interactions ; Cell signaling ; Chemokines ; Communication ; Consortia ; Coordination compounds ; Decidua ; Decidua - cytology ; Decidua - immunology ; Decidua - metabolism ; Eclampsia ; Female ; Fetus - cytology ; Fetus - immunology ; Fetus - metabolism ; Fetuses ; Gene expression ; Genomes ; Genomics ; Histocompatibility, Maternal-Fetal - immunology ; Humans ; Immune response ; Immunomodulation ; Implants ; Killer cells ; Killer Cells, Natural - cytology ; Killer Cells, Natural - immunology ; Ligands ; Lymphocytes ; Medicin och hälsovetenskap ; Molecular interactions ; Mucosa ; Natural killer cells ; Observations ; Parameter estimation ; Physiological aspects ; Placenta ; Placenta - cytology ; Placenta - immunology ; Placenta - metabolism ; Pre-eclampsia ; Preeclampsia ; Pregnancy ; Pregnancy - immunology ; Reproduction ; RNA, Small Cytoplasmic - genetics ; Robinson, J ; Sequence Analysis, RNA ; Single-Cell Analysis ; Stillbirth ; Stromal cells ; Stromal Cells - cytology ; Stromal Cells - metabolism ; Success ; T cell receptors ; Transcriptome ; Trophoblasts - cytology ; Trophoblasts - immunology ; Trophoblasts - metabolism ; Uterus ; Veins & arteries
Is Part Of: Nature (London), 2018-11, Vol.563 (7731), p.347-353
Description: During early human pregnancy the uterine mucosa transforms into the decidua, into which the fetal placenta implants and where placental trophoblast cells intermingle and communicate with maternal cells. Trophoblast-decidual interactions underlie common diseases of pregnancy, including pre-eclampsia and stillbirth. Here we profile the transcriptomes of about 70,000 single cells from first-trimester placentas with matched maternal blood and decidual cells. The cellular composition of human decidua reveals subsets of perivascular and stromal cells that are located in distinct decidual layers. There are three major subsets of decidual natural killer cells that have distinctive immunomodulatory and chemokine profiles. We develop a repository of ligand-receptor complexes and a statistical tool to predict the cell-type specificity of cell-cell communication via these molecular interactions. Our data identify many regulatory interactions that prevent harmful innate or adaptive immune responses in this environment. Our single-cell atlas of the maternal-fetal interface reveals the cellular organization of the decidua and placenta, and the interactions that are critical for placentation and reproductive success.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 0028-0836
ISSN: 1476-4687
EISSN: 1476-4687
DOI: 10.1038/s41586-018-0698-6
PMID: 30429548
Source: ProQuest One Psychology
MEDLINE
SWEPUB Freely available online
ProQuest Central

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Single-cell reconstruction of the early maternal-fetal interface in humans

COPYRIGHT 2018 Nature Publishing Group ;COPYRIGHT 2018 Nature Publishing Group ;Copyright Nature Publishing Group Nov 15, 2018 ;ISSN: 0028-0836 ;ISSN: 1476-4687 ;EISSN: 1476-4687 ;DOI: 10.1038/s41586-018-0698-6 ;PMID: 30429548

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