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Interleukin-17 in human inflammatory diseases

Postȩpy dermatologii i alergologii, 2014-08, Vol.31 (4), p.256-261 [Peer Reviewed Journal]

Copyright Termedia Publishing House 2014 ;Copyright © 2014 Termedia 2014 ;ISSN: 1642-395X ;EISSN: 2299-0046 ;DOI: 10.5114/pdia.2014.40954 ;PMID: 25254011

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  • Title:
    Interleukin-17 in human inflammatory diseases
  • Author: Shabgah, Arezoo Gowhari ; Fattahi, Ebrahim ; Shahneh, Fatemeh Zare
  • Subjects: Review Papers
  • Is Part Of: Postȩpy dermatologii i alergologii, 2014-08, Vol.31 (4), p.256-261
  • Description: Human Th17 pro-inflammatory cells are currently defined as cells that produce IL-17A and F, tumor necrosis factor (TNF)-α, IL-6, IL-21, IL-22 and IL-23. Recently discovered related molecules are forming a family of cytokines, the IL-17 family, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. The associated receptors for the IL-17 family identified are IL-17R, IL-17RH1, IL-17RL (receptor like), IL-17RD and IL-17RE. This review introduces the roles of IL-17 and Th17 cells in human autoimmune diseases. Studies have shown that T cells with inflammatory effects on epithelial, endothelial and fibroblast cells express IL-17. Th17 cells are supposed to be involved in various autoimmune diseases, such as rheumatoid arthritis, psoriasis, multiple sclerosis, and inflammatory bowel diseases. Base on the biologic functions and regulation, IL-17 has regulatory roles in host defense and chronic inflammation which result in tissue damage and autoimmunity. So the IL-17 links links innate and adaptive immunity and has both beneficial and pathological effects on the immune system. This paper will focus on the possible roles of IL-17 in autoimmune diseases, a fundamental player in immune regulation.
  • Publisher: Poland: Termedia Publishing House
  • Language: English;Polish
  • Identifier: ISSN: 1642-395X
    EISSN: 2299-0046
    DOI: 10.5114/pdia.2014.40954
    PMID: 25254011
  • Source: PubMed Central
    ProQuest Central
    DOAJ Directory of Open Access Journals
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