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Minocycline Treatment of Genital Infections Caused by Chlamydia Trachomatis (C. trachomatis)

Kansenshogaku Zasshi, 1985/08/20, Vol.59(8), pp.824-830

The Japansese Association for Infectious Diseases ;ISSN: 0387-5911 ;EISSN: 1884-569X ;DOI: 10.11150/kansenshogakuzasshi1970.59.824 ;PMID: 3937875

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  • Title:
    Minocycline Treatment of Genital Infections Caused by Chlamydia Trachomatis (C. trachomatis)
  • Author: KOJIMA, Hiroyuki ; MORI, Chuzou
  • Subjects: Adolescent ; Adult ; Chlamydia Infections - drug therapy ; Chlamydia trachomatis ; Chlamydia trachomatis infections ; Clinical study ; Female ; Genital Diseases, Female - drug therapy ; Genital Diseases, Male - drug therapy ; Humans ; Male ; Middle Aged ; Minocycline ; Minocycline - administration & dosage ; Minocycline - therapeutic use ; Non-gonococcal urethritis ; Tetracyclines - therapeutic use
  • Is Part Of: Kansenshogaku Zasshi, 1985/08/20, Vol.59(8), pp.824-830
  • Description: The clinical effect of minocycline on genital infections by C. trachomatis was investigated. Fifty cases of male C. trachomatis urethritis, five cases of C. trachomatis epididymitis and five cases of C. trachomatis cervicitis were subjected to the study. Minocycline was given orally with the dose of 200 or 300mg daily for 7 to 14 days. Direct demonstration of C. trachomatis using fluorescein-conjugated anti C. trachomatis species-specific monoclonal antibody (CTFA) was performed both prior to and after the treatment with minocycline. C. trachomatis was identified in all cases during pre-treatment period, but was negative without exception in all cases after treatment regardless of dose and duration. Subjective symptoms were variable from patient to patient, might disappear after administration of antiinflammatory agent, were lacking in some patients with urethritis and in all patients with cervicitis and therefore were found to be an unreliable index for asessment of the treatment of C. trachomatis genital infections. Dizzyness were noted among the patients treated with the daily dose of 300 mg, but these side effects were not severe enough to discontinue the treatment. From above results it is concluded that minocycline is effective in the treatment of C. trachomatis genital infections.
  • Publisher: Japan: The Japanese Association for Infectious Diseases
  • Language: Japanese;English
  • Identifier: ISSN: 0387-5911
    EISSN: 1884-569X
    DOI: 10.11150/kansenshogakuzasshi1970.59.824
    PMID: 3937875
  • Source: MEDLINE
    Alma/SFX Local Collection
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