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Idiopathic/Iatrogenic Left Bundle Branch Block-Induced Reversible Left Ventricle Dysfunction: JACC State-of-the-Art Review

Journal of the American College of Cardiology, 2018-12, Vol.72 (24), p.3177-3188 [Peer Reviewed Journal]

Copyright © 2018 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. ;Copyright Elsevier Limited Dec 18, 2018 ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0735-1097 ;EISSN: 1558-3597 ;DOI: 10.1016/j.jacc.2018.09.069 ;PMID: 30545456

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  • Title:
    Idiopathic/Iatrogenic Left Bundle Branch Block-Induced Reversible Left Ventricle Dysfunction: JACC State-of-the-Art Review
  • Author: Auffret, Vincent ; Martins, Raphaël P ; Daubert, Claude ; Leclercq, Christophe ; Le Breton, Hervé ; Mabo, Philippe ; Donal, Erwan
  • Subjects: Abnormalities ; Animal models ; Aorta ; Aortic valve ; Bioengineering ; Cardiomyopathy ; Cardiovascular disease ; Clinical trials ; Disease prevention ; Electrocardiography ; Epidemiology ; Heart ; Heart diseases ; Life Sciences ; Medical research ; Mortality ; Synchronism ; Synchronization ; Ventricle
  • Is Part Of: Journal of the American College of Cardiology, 2018-12, Vol.72 (24), p.3177-3188
  • Description: Idiopathic or iatrogenic left bundle branch block (LBBB) is a unique model of electro-mechanical ventricular dyssynchrony with concordant changes in electrical activation sequence and mechanical ventricle synchronization. In chronic animal models, isolated LBBB induces structural remodeling with progressive left ventricular (LV) dysfunction. Most abnormalities can be reverted after cardiac resynchronization therapy (CRT). In humans, 2 principal models of LBBB dyssynchronopathy can be observed: the chronic model of isolated LBBB and an acute iatrogenic model of new-onset LBBB after aortic valve interventions. Although epidemiological evidence and clinical data need to be strengthened, there is a strong presumption that they may lead to LBBB-induced cardiomyopathy and benefit from CRT to prevent progression to heart failure. A large cohort study with prospective follow-up would be required to better define actual incidence, evolution over time, and predisposing factors. Parallel randomized CRT clinical trials should be conducted in selected at-risk populations: namely, patients with persistent LBBB after transcatheter aortic valve replacement.
  • Publisher: United States: Elsevier Limited
  • Language: English
  • Identifier: ISSN: 0735-1097
    EISSN: 1558-3597
    DOI: 10.1016/j.jacc.2018.09.069
    PMID: 30545456
  • Source: GFMER Free Medical Journals
    Alma/SFX Local Collection
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