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Targeting the Inflammasome in Cardiovascular Disease

JACC. Basic to translational science, 2022-01, Vol.7 (1), p.84-98 [Peer Reviewed Journal]

2022 The Authors ;2022 The Authors. ;info:eu-repo/semantics/openAccess ;2022 The Authors 2022 ;ISSN: 2452-302X ;EISSN: 2452-302X ;DOI: 10.1016/j.jacbts.2021.08.006 ;PMID: 35128212

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  • Title:
    Targeting the Inflammasome in Cardiovascular Disease
  • Author: Olsen, Maria Belland ; Gregersen, Ida ; Sandanger, Øystein ; Yang, Kuan ; Sokolova, Marina ; Halvorsen, Bente E. ; Gullestad, Lars ; Broch, Kaspar ; Aukrust, Pål ; Louwe, Mieke C.
  • Subjects: atherosclerosis ; cardiovascular disease ; heart failure ; IL-1 ; inflammasome ; NLRP3 ; State-of-the-Art Review
  • Is Part Of: JACC. Basic to translational science, 2022-01, Vol.7 (1), p.84-98
  • Description: •Development of cardiovascular disease and inflammation are heavily intertwined, and inflammasome activation is thought play an important role in this interaction.•This review provides an overview of preclinical and clinical studies supporting inflammasomes as a therapeutic target in atherosclerosis and heart failure.•Future studies exploring direct inflammasome inhibition, either NLRP3 or the lesser-studied inflammasomes, are also discussed. The pathogenesis of cardiovascular disease (CVD) is complex and multifactorial, and inflammation plays a central role. Inflammasomes are multimeric protein complexes that are activated in a 2-step manner in response to infection or tissue damage. Upon activation the proinflammatory cytokines, interleukins-1β and -18 are released. In the last decade, the evidence that inflammasome activation plays an important role in CVD development became stronger. We discuss the role of different inflammasomes in the pathogenesis of CVD, focusing on atherosclerosis and heart failure. This review also provides an overview of existing experimental studies and clinical trials on inflammasome inhibition as a therapeutic target in these disorders. [Display omitted]
  • Publisher: United States: Elsevier Inc
  • Language: English;Norwegian
  • Identifier: ISSN: 2452-302X
    EISSN: 2452-302X
    DOI: 10.1016/j.jacbts.2021.08.006
    PMID: 35128212
  • Source: PubMed Central (Open access)
    NORA Norwegian Open Research Archives
    DOAJ Directory of Open Access Journals
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