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제2형 당뇨병환자에서 각 대사증후군의 정의(WHO, NCEP-ATP 3, IDF)에 따른 심혈관질환의 예측능 비교

Diabetes and Metabolism Journal, 2008, 32(2), , pp.157-164 [Peer Reviewed Journal]

COPYRIGHT(C) KYOBO BOOK CENTRE ALL RIGHTS RESERVED ;ISSN: 2233-6079 ;EISSN: 2233-6087

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  • Title:
    제2형 당뇨병환자에서 각 대사증후군의 정의(WHO, NCEP-ATP 3, IDF)에 따른 심혈관질환의 예측능 비교
  • Author: 임동미 ; Dong Mee Lim ; 박근용 ; Keun Young Park ; 고관표 ; Gwan Pyo Koh
  • Subjects: Cardiovascular disease ; Diabetes mellitus ; Metabolic syndrome ; 내과학
  • Is Part Of: Diabetes and Metabolism Journal, 2008, 32(2), , pp.157-164
  • Description: Background: Metabolic syndrome (MetS) is constellation of cardiovascular risk factors. There are three typically used definitions of MetS proposed by WHO, IDF and NCEP-ATP III. We conducted this study to compare the associations of MetS by WHO, IDF and NCEP-ATP III definition to various metabolic markers of coronary heart diseases in Korean type 2 diabetes patients. Methods: We enrolled 151 Korean type 2 diabetes patients in one hospital. Anthropometric and biochemical parameters, including high-sensitivity C-reactive protein (hsCRP), homocysteine, uric acid were measured. And then, we divided MetS group from non-MetS group according to three other definitions. Results: Serum hsCRP level was higher in those with MetS group than non-MetS group by WHO definition (0.33 ± 0.36 mg/dL vs 0.18 ± 0.26 mg/dL, P < 0.001). But, there are no difference in MetS group and non-MetS group by IDF and NCEP-ATPIII definition. (By IDF, 0.28 ± 0.31 mg/dL vs 0.25 ± 0.34 mg/dL, P= 0.64; By NCEP-ATP III, 0.28 ± 0.33 mg/dL vs 0.22 ± 0.32 mg/dL, P = 0.41). Uric acid and homocysteine levels were higher in those with MetS by WHO definition (P < 0.05). Similarly, analyses according to IDF and NCEP ATP III definition showed no significant difference. Conclusion: In conclusion, WHO definition of MetS has a stronger relationship with the biochemical markers of coronary heart disease in Korean type 2 diabetes patients.
  • Publisher: 대한당뇨병학회
  • Language: Korean
  • Identifier: ISSN: 2233-6079
    EISSN: 2233-6087
  • Source: DOAJ Directory of Open Access Journals
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