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Socio-demographic variation in stage at diagnosis of breast, bladder, colon, endometrial, lung, melanoma, prostate, rectal, renal and ovarian cancer in England and its population impact

British journal of cancer, 2021-03, Vol.124 (7), p.1320-1329 [Peer Reviewed Journal]

The Author(s), under exclusive licence to Cancer Research UK 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s), under exclusive licence to Cancer Research UK 2021 ;ISSN: 0007-0920 ;EISSN: 1532-1827 ;DOI: 10.1038/s41416-021-01279-z ;PMID: 33564123

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Title:
Socio-demographic variation in stage at diagnosis of breast, bladder, colon, endometrial, lung, melanoma, prostate, rectal, renal and ovarian cancer in England and its population impact
Author: Barclay, M E ; Abel, G A ; Greenberg, David C ; Rous, B ; Lyratzopoulos, G
Subjects: Adult ; Aged ; Aged, 80 and over ; Breast ; Breast Neoplasms - diagnosis ; Breast Neoplasms - epidemiology ; Cancer ; Colon ; Colonic Neoplasms - diagnosis ; Colonic Neoplasms - epidemiology ; Demography ; Diagnosis ; Endometrial Neoplasms - diagnosis ; Endometrial Neoplasms - epidemiology ; Endometrium ; England - epidemiology ; Female ; Follow-Up Studies ; Humans ; Kidney Neoplasms - diagnosis ; Kidney Neoplasms - epidemiology ; Lung cancer ; Lung Neoplasms - diagnosis ; Lung Neoplasms - epidemiology ; Male ; Melanoma ; Melanoma - diagnosis ; Melanoma - epidemiology ; Middle Aged ; Neoplasms - diagnosis ; Neoplasms - epidemiology ; Ovarian cancer ; Ovarian Neoplasms - diagnosis ; Ovarian Neoplasms - epidemiology ; Prognosis ; Prostate ; Prostate cancer ; Prostatic Neoplasms - diagnosis ; Prostatic Neoplasms - epidemiology ; Rectal Neoplasms - diagnosis ; Rectal Neoplasms - epidemiology ; Rectum ; Sociodemographics ; Socioeconomic Factors ; Solid tumors ; Tumors ; Urinary Bladder Neoplasms - diagnosis ; Urinary Bladder Neoplasms - epidemiology
Is Part Of: British journal of cancer, 2021-03, Vol.124 (7), p.1320-1329
Description: Stage at diagnosis strongly predicts cancer survival and understanding related inequalities could guide interventions. We analysed incident cases diagnosed with 10 solid tumours included in the UK government target of 75% of patients diagnosed in TNM stage I/II by 2028. We examined socio-demographic differences in diagnosis at stage III/IV vs. I/II. Multiple imputation was used for missing stage at diagnosis (9% of tumours). Of the 202,001 cases, 57% were diagnosed in stage I/II (an absolute 18% 'gap' from the 75% target). The likelihood of diagnosis at stage III/IV increased in older age, though variably by cancer site, being strongest for prostate and endometrial cancer. Increasing level of deprivation was associated with advanced stage at diagnosis for all sites except lung and renal cancer. There were, inconsistent in direction, sex inequalities for four cancers. Eliminating socio-demographic inequalities would translate to 61% of patients with the 10 studied cancers being diagnosed at stage I/II, reducing the gap from target to 14%. Potential elimination of socio-demographic inequalities in stage at diagnosis would make a substantial, though partial, contribution to achieving stage shift targets. Earlier diagnosis strategies should additionally focus on the whole population and not only the high-risk socio-demographic groups.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 0007-0920
EISSN: 1532-1827
DOI: 10.1038/s41416-021-01279-z
PMID: 33564123
Source: Geneva Foundation Free Medical Journals at publisher websites
AUTh Library subscriptions: ProQuest Central
MEDLINE
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Socio-demographic variation in stage at diagnosis of breast, bladder, colon, endometrial, lung, melanoma, prostate, rectal, renal and ovarian cancer in England and its population impact

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