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New opportunities in the treatment of asthenic symptoms after a new coronavirus infection
Medicinskij sovet, 2022-04 (6), p.24-35
[Peer Reviewed Journal]
ISSN: 2079-701X ;EISSN: 2658-5790 ;DOI: 10.21518/2079-701X-2022-16-6-24-35
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Title:
New opportunities in the treatment of asthenic symptoms after a new coronavirus infection
Author:
Shishkova, V. N.
;
Martynov, A. I.
Subjects:
asthenia
;
cardiovascular disease
;
cerebrovascular disease
;
meldonium
;
new coronavirus infection
;
postvascular syndrome
Is Part Of:
Medicinskij sovet, 2022-04 (6), p.24-35
Description:
Introduction . Asthenia is an urgent problem during the pandemic of new coronavirus infection (COVID-19) because of its high frequency regardless of the severity of the disease. The purpose of this subanalysis of data from the multicenter controlled randomized clinical trial TONUS was to evaluate the efficacy and safety of meldonium therapy for аsthenia in COVID-19 survivors. Materials and methods. A total of 880 patients with asthenia who underwent COVID-19 within the last 6 months were included in the analysis. The efficacy of asthenia therapy was assessed by the MFI-20 scale, Schulte tables, and the General Clinical Impression (CGI) scale. All patients were previously randomized in two parallel branches of the TONUS study, including patients without concomitant disease in TONUS-1 (who received meldonium 500 mg/day for 14 days in the main group) and patients with cardiovascular or cerebrovascular disease in TONUS-2, who received meldonium at a dose of 1000 mg/day for 42 days in the main group. In both arms of the study, the drugs in the comparison groups were multivitamin complexes. Results . For the TONUS-1 groups.In the group of patients receiving meldonium compared with the control group (p < 0.001): total MFI-20 score decreased and was 31 (25; 40); MFI-20 –35 (–46; 23); performance value –5 (–11; –2) seconds; proportion of patients with significant improvement (by CGI-I) by the end of follow-up was 92.8%. For TONUS-2 groups.In the group of patients receiving meldonium compared with the control group (p < 0.001): total MFI-20 score decreased to 35 (27; 44); MFI-20 –34 (–46; –21), performance value –5 (–11; –2), proportion of patients with significant improvement (by CGI-I) by end of follow-up – 90.8%. Conclusion . Significant positive dynamics and regression of asthenia were noted in the groups of patients receiving meldonium in comparison with the control groups.
Publisher:
Remedium Group LLC
Language:
English;Russian
Identifier:
ISSN: 2079-701X
EISSN: 2658-5790
DOI: 10.21518/2079-701X-2022-16-6-24-35
Source:
DOAJ Directory of Open Access Journals
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