skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults

The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess ;ISSN: 1078-8956 ;EISSN: 1546-170X ;DOI: 10.1038/s41591-023-02620-0

Full text available

Citations Cited by
  • Title:
    Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults
  • Author: Bosch de Basea i Gómez, Magda, 1982 ; Thierry-Chef, Isabelle ; Harbron, Richard W ; Figuerola, Jordi ; Peiró Martínez, Anna ; Cardis, Elisabeth
  • Subjects: Epidemiology ; Risk factors
  • Description: Over one million European children undergo computed tomography (CT) scans annually. Although moderate- to high-dose ionizing radiation exposure is an established risk factor for hematological malignancies, risks at CT examination dose levels remain uncertain. Here we followed up a multinational cohort (EPI-CT) of 948,174 individuals who underwent CT examinations before age 22 years in nine European countries. Radiation doses to the active bone marrow were estimated on the basis of body part scanned, patient characteristics, time period and inferred CT technical parameters. We found an association between cumulative dose and risk of all hematological malignancies, with an excess relative risk of 1.96 (95% confidence interval 1.10 to 3.12) per 100 mGy (790 cases). Similar estimates were obtained for lymphoid and myeloid malignancies. Results suggest that for every 10,000 children examined today (mean dose 8 mGy), 1-2 persons are expected to develop a hematological malignancy attributable to radiation exposure in the subsequent 12 years. Our results strengthen the body of evidence of increased cancer risk at low radiation doses and highlight the need for continued justification of pediatric CT examinations and optimization of doses. This work was partly supported by the European Community’s Seventh Framework Programme (FP7/20011-2017) (grant number 269912 - EPI-CT: Epidemiological study to quantify risks for paediatric computerised tomography and to optimise doses) (A.K., E.C., M.H., M.-O.B., A.J., H.O., H.E., C.J., M.B., M.K. and K.K.). In Spain, this study was partially supported by grants (E.C. and M.B.B.) from the Instituto de Salud Carlos III-ISCIII from the Spanish Government (reference: PI16/00120) cofunded by FEDER funds/European Regional Development Fund (ERDF)—a way to build Europe. Additionally, complementary Spanish funding was received from the Consejo de Seguridad Nuclear (E.C.) and M.B.B. was the recipient of a fellowship of the Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP) for a short stay abroad at Newcastle University. ISGlobal also acknowledges support from the grant CEX2018-000806-S funded by MCIN/AEI/10.13039/501100011033, from the Generalitat de Catalunya through the CERCA Program and from the Secretariat of Universities and Research of the Department of Business and Knowledge of the Generalitat of Catalonia through AGAUR (the Catalan Agency for Management of University and Research Grants) (Project 2017 SGR 1487) to EC.
  • Publisher: Nature Research
  • Creation Date: 2023
  • Language: English
  • Identifier: ISSN: 1078-8956
    EISSN: 1546-170X
    DOI: 10.1038/s41591-023-02620-0
  • Source: Repositori Digital de la UPF (Universitat Pompeu Fabra)
    ProQuest Central
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait