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Effect of a low glycemic index Mediterranean diet on non-alcoholic fatty liver disease. A randomized controlled clinici trial

The Journal of nutrition, health & aging, 2017-04, Vol.21 (4), p.404-412 [Peer Reviewed Journal]

Serdi and Springer-Verlag France 2017 ;The journal of nutrition, health & aging is a copyright of Springer, 2017. ;ISSN: 1279-7707 ;EISSN: 1760-4788 ;DOI: 10.1007/s12603-016-0809-8 ;PMID: 28346567

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Title:
Effect of a low glycemic index Mediterranean diet on non-alcoholic fatty liver disease. A randomized controlled clinici trial
Author: Misciagna, G. ; del Pilar Díaz, M. ; Caramia, D. V. ; Bonfiglio, C. ; Franco, I. ; Noviello, M. R. ; Chiloiro, M. ; Abbrescia, D. I. ; Mirizzi, A. ; Tanzi, M. ; Caruso, M. G. ; Correale, M. ; Reddavide, R. ; Inguaggiato, R. ; Cisternino, A. M. ; Osella, Alberto Rubén
Subjects: Adult ; Aged ; Aging ; Blood Glucose - physiology ; Blood Pressure - physiology ; Body Height - physiology ; Body Weight - physiology ; Diabetes Mellitus, Type 2 - prevention & control ; Diet, Mediterranean ; Double-Blind Method ; Female ; Geriatrics/Gerontology ; Glycemic Index - physiology ; Humans ; Insulin - blood ; Italy ; Life Style ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neurosciences ; Non-alcoholic Fatty Liver Disease - blood ; Non-alcoholic Fatty Liver Disease - diet therapy ; Nutrition ; Primary Care Medicine ; Quality of Life Research ; Surveys and Questionnaires
Is Part Of: The Journal of nutrition, health & aging, 2017-04, Vol.21 (4), p.404-412
Description: Introduction Non-Alcoholic Fatty Liver Disease (NAFLD) is currently the most common form of liver disease worldwide affecting all ages and ethnic groups and it has become a consistent threat even in young people. Our aim was to estimate the effect of a Low Glycemic Index Mediterranean Diet (LGIMD) on the NAFLD score as measured by a Liver Ultrasonography (LUS). Design NUTRIzione in EPAtologia (NUTRIEPA) is a population-based Double-Blind RCT. Data were collected in 2011 and analyzed in 2013-14. Setting/participants 98 men and women coming from Putignano (Puglia, Southern Italy) were drawn from a previous randomly sampled population-based study and identified as having moderate or severe NAFLD. Intervention The intervention strategy was the assignment of a LGIMD or a control diet. Outcome measures The main outcome measure was NAFLD score, defined by LUS. Results After randomization, 50 subjects were assigned to a LGIMD and 48 to a control diet. The study lasted six months and all participants were subject to monthly controls/checks. Adherence to the LGIMD as measured by Mediterranean Adequacy Index (MAI) showed a median of 10.1. A negative interaction between time and LGIMD on the NAFLD score (-4.14, 95% CI -6.78,-1.49) was observed, and became more evident at the sixth month (-4.43, 95%CI -7.15, -1.71). A positive effect of the interaction among LGIMD, time and age (Third month: 0.07, 95% CI 0.02, 0.12; Sixth month: 0.08, 95% CI 0.03,0.13) was also observed. Conclusions LGIMD was found to decrease the NAFLD score in a relatively short time. Encouraging those subjects who do not seek medical attention but still have NAFLD to follow a LGIMD and other life-style interventions, may reduce the degree of severity of the disease. Dietary intervention of this kind, could also form the cornerstone of primary prevention of Type 2 Diabetes Mellitus (T2DM) and cardiovascular disease.
Publisher: Paris: Springer Paris
Language: English
Identifier: ISSN: 1279-7707
EISSN: 1760-4788
DOI: 10.1007/s12603-016-0809-8
PMID: 28346567
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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Effect of a low glycemic index Mediterranean diet on non-alcoholic fatty liver disease. A randomized controlled clinici trial

Serdi and Springer-Verlag France 2017 ;The journal of nutrition, health & aging is a copyright of Springer, 2017. ;ISSN: 1279-7707 ;EISSN: 1760-4788 ;DOI: 10.1007/s12603-016-0809-8 ;PMID: 28346567

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