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The InterPro protein families and domains database: 20 years on

Nucleic Acids Research, 2021-01, Vol.49 (D1), p.D344-D354 [Peer Reviewed Journal]

The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research. 2021 ;The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research. ;2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 0305-1048 ;EISSN: 1362-4962 ;DOI: 10.1093/nar/gkaa977 ;PMID: 33156333

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Title:
The InterPro protein families and domains database: 20 years on
Author: Blum, Matthias ; Chang, Hsin-Yu ; Chuguransky, Sara ; Grego, Tiago ; Kandasaamy, Swaathi ; Mitchell, Alex ; Nuka, Gift ; Paysan-Lafosse, Typhaine ; Qureshi, Matloob ; Raj, Shriya ; Richardson, Lorna ; Salazar, Gustavo A ; Williams, Lowri ; Bork, Peer ; Bridge, Alan ; Gough, Julian ; Haft, Daniel H ; Letunic, Ivica ; Marchler-Bauer, Aron ; Mi, Huaiyu ; Natale, Darren A ; Necci, Marco ; Orengo, Christine A ; Pandurangan, Arun P ; Rivoire, Catherine ; Sigrist, Christian J A ; Sillitoe, Ian ; Thanki, Narmada ; Thomas, Paul D ; Tosatto, Silvio C E ; Wu, Cathy H ; Bateman, Alex ; Finn, Robert D
Subjects: Amino Acid Sequence ; COVID-19 - metabolism ; Database Issue ; Databases, Protein ; Internet ; Molecular Sequence Annotation ; Protein Domains ; Protein Interaction Maps ; Proteins - chemistry ; SARS-CoV-2 - metabolism ; Sequence Alignment
Is Part Of: Nucleic Acids Research, 2021-01, Vol.49 (D1), p.D344-D354
Description: Abstract The InterPro database (https://www.ebi.ac.uk/interpro/) provides an integrative classification of protein sequences into families, and identifies functionally important domains and conserved sites. InterProScan is the underlying software that allows protein and nucleic acid sequences to be searched against InterPro's signatures. Signatures are predictive models which describe protein families, domains or sites, and are provided by multiple databases. InterPro combines signatures representing equivalent families, domains or sites, and provides additional information such as descriptions, literature references and Gene Ontology (GO) terms, to produce a comprehensive resource for protein classification. Founded in 1999, InterPro has become one of the most widely used resources for protein family annotation. Here, we report the status of InterPro (version 81.0) in its 20th year of operation, and its associated software, including updates to database content, the release of a new website and REST API, and performance improvements in InterProScan.
Publisher: England: Oxford University Press
Language: English
Identifier: ISSN: 0305-1048
EISSN: 1362-4962
DOI: 10.1093/nar/gkaa977
PMID: 33156333
Source: Coronavirus Research Database

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The InterPro protein families and domains database: 20 years on

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