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In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19

Cell Metabolism, 2020-08, Vol.32 (2), p.176-187.e4 [Peer Reviewed Journal]

2020 Elsevier Inc. ;Copyright © 2020 Elsevier Inc. All rights reserved. ;2020. Not withstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://www.elsevier.com/legal/elsevier-website-terms-and-conditions ;2020 Elsevier Inc. 2020 Elsevier Inc. ;ISSN: 1550-4131 ;EISSN: 1932-7420 ;DOI: 10.1016/j.cmet.2020.06.015 ;PMID: 32592657

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Title:
In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19
Author: Zhang, Xiao-Jing ; Qin, Juan-Juan ; Cheng, Xu ; Shen, Lijun ; Zhao, Yan-Ci ; Yuan, Yufeng ; Lei, Fang ; Chen, Ming-Ming ; Yang, Huilin ; Bai, Liangjie ; Song, Xiaohui ; Lin, Lijin ; Xia, Meng ; Zhou, Feng ; Zhou, Jianghua ; She, Zhi-Gang ; Zhu, Lihua ; Ma, Xinliang ; Xu, Qingbo ; Ye, Ping ; Chen, Guohua ; Liu, Liming ; Mao, Weiming ; Yan, Youqin ; Xiao, Bing ; Lu, Zhigang ; Peng, Gang ; Liu, Mingyu ; Yang, Jun ; Yang, Luyu ; Zhang, Changjiang ; Lu, Haofeng ; Xia, Xigang ; Wang, Daihong ; Liao, Xiaofeng ; Wei, Xiang ; Zhang, Bing-Hong ; Zhang, Xin ; Yang, Juan ; Zhao, Guang-Nian ; Zhang, Peng ; Liu, Peter P. ; Loomba, Rohit ; Ji, Yan-Xiao ; Xia, Jiahong ; Wang, Yibin ; Cai, Jingjing ; Guo, Jiao ; Li, Hongliang
Subjects: ACEi/ARB ; Aged ; Angiotensin-Converting Enzyme 2 ; Angiotensin-Converting Enzyme Inhibitors - therapeutic use ; Antihypertensive Agents - therapeutic use ; Betacoronavirus - drug effects ; Comorbidity ; Coronavirus Infections - drug therapy ; Coronavirus Infections - mortality ; COVID-19 ; Cytokine Release Syndrome - drug therapy ; Drug Repositioning - methods ; Drug Therapy, Combination ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Hypertension - drug therapy ; Male ; Middle Aged ; mortality ; Pandemics ; Peptidyl-Dipeptidase A - drug effects ; Pneumonia, Viral - drug therapy ; Pneumonia, Viral - mortality ; Retrospective Studies ; SARS-COV-2 ; statin
Is Part Of: Cell Metabolism, 2020-08, Vol.32 (2), p.176-187.e4
Description: Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk of SARS-CoV-2 viral entry by inducing ACE2 expression. Here, we performed a retrospective study on 13,981 patients with COVID-19 in Hubei Province, China, among which 1,219 received statins. Based on a mixed-effect Cox model after propensity score-matching, we found that the risk for 28-day all-cause mortality was 5.2% and 9.4% in the matched statin and non-statin groups, respectively, with an adjusted hazard ratio of 0.58. The statin use-associated lower risk of mortality was also observed in the Cox time-varying model and marginal structural model analysis. These results give support for the completion of ongoing prospective studies and randomized controlled trials involving statin treatment for COVID-19, which are needed to further validate the utility of this class of drugs to combat the mortality of this pandemic. [Display omitted] •Statin treatment among 13,981 patients with COVID-19 was retrospectively studied•Statin use in this cohort was associated with a lower risk of all-cause mortality•Adding an ACE inhibitor or an ARB did not affect statin-associated outcome in the cohort•The benefit of statins among this cohort may be due to immunomodulatory benefits Statins have anti-inflammatory benefits and were suggested as an adjunct therapy for COVID-19. But statins may increase the expression of ACE2, the receptor for SARS-CoV-2. Here, Zhang et al. retrospectively analyzed 13,981 COVID-19 cases and found that in-hospital statin use is associated with a lower risk of all-cause mortality.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 1550-4131
EISSN: 1932-7420
DOI: 10.1016/j.cmet.2020.06.015
PMID: 32592657
Source: Coronavirus Research Database

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In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19

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