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Aqueous Methanol Extracts of Cochlospermum tinctorium (A. Rich) Possess Analgesic and Anti-inflammatory Activities

Journal of young pharmacists, 2011-07, Vol.3 (3), p.237-242 [Peer Reviewed Journal]

COPYRIGHT 2011 Medknow Publications and Media Pvt. Ltd. ;Copyright Medknow Publications & Media Pvt Ltd Jul 2011 ;Journal of Young Pharmacists 2011 ;ISSN: 0975-1483 ;EISSN: 0975-1505 ;DOI: 10.4103/0975-1483.83774 ;PMID: 21897665

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  • Title:
    Aqueous Methanol Extracts of Cochlospermum tinctorium (A. Rich) Possess Analgesic and Anti-inflammatory Activities
  • Author: Ahmed, Ts ; Magaji, Mg ; Yaro, Ah ; Musa, Am ; Adamu, Ak
  • Subjects: Acids ; Aqueous solutions ; Gastrointestinal diseases ; Health aspects ; Laboratory animals ; Materia medica, Vegetable ; Medicine, Botanic ; Medicine, Herbal ; Pain management ; Pharmacology ; Physiological aspects ; Phytochemicals ; Plant extracts
  • Is Part Of: Journal of young pharmacists, 2011-07, Vol.3 (3), p.237-242
  • Description: Cochlopermum tinctorium A. Rich. (Cochlospermaceae) is a commonly used medicinal plant in the West Africa sub-region for the management of various conditions including pain and inflammatory conditions. In the present study, we report the analgesic and anti-inflammatory activities of the aqueous methanol leaf (20-80 mg/kg), root (7.5-30 mg/kg), and root bark (20-80 mg/kg) extracts of the plant. The analgesic potentials of the extracts were studied using acetic acid induced writhing and hot plate tests in mice while the anti-inflammatory activity was investigated using carrageenan-induced paw edema in rats.The extracts significantly and dose dependently inhibited the acetic acid-induced writhing in mice. However, the highest protection against writhing was produced by aqueous methanol leaf extract at the dose of 80 mg/kg (96.65%) which even was greater than that of the standard agent, ketoprofen (82.30%). The extracts did not significantly increase mean latency of response in the hot plate test. However, aqueous methanol root bark extract at the dose of 20 mg/kg significantly (P < 0.05) increased the mean latency of pain response. While the extracts of the root and root bark extracts of the plant afforded non dose-dependent protection against carrageenan-induced edema, the aqueous methanol leaf extract significantly and dose-dependently inhibited carrageenan-induced hind paw edema at the end of the third hour.The present study suggests that the aqueous methanol leaf, root, and root bark extracts of Cochlopermum tinctorium possess analgesic and anti-inflammatory activities which lend some credence to the ethnomedical claim of the use of the plant in the management of pain and inflammatory conditions.
  • Publisher: India: Medknow Publications and Media Pvt. Ltd
  • Language: English
  • Identifier: ISSN: 0975-1483
    EISSN: 0975-1505
    DOI: 10.4103/0975-1483.83774
    PMID: 21897665
  • Source: GFMER Free Medical Journals
    PubMed Central
    Alma/SFX Local Collection
    ProQuest Central
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