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The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries

PloS one, 2020-06, Vol.15 (6), p.e0234765-e0234765 [Peer Reviewed Journal]

COPYRIGHT 2020 Public Library of Science ;COPYRIGHT 2020 Public Library of Science ;2020 Grant et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2020 Grant et al 2020 Grant et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0234765 ;PMID: 32574165

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Title:
The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries
Author: Grant, Michael C ; Geoghegan, Luke ; Arbyn, Marc ; Mohammed, Zakaria ; McGuinness, Luke ; Clarke, Emily L ; Wade, Ryckie G
Hirst, Jennifer A.
Subjects: Adult ; Adults ; Analysis ; Bias ; Biology and Life Sciences ; Coronavirus infections ; Coronavirus Infections - epidemiology ; Coronavirus Infections - pathology ; Coronaviruses ; Cough ; Cough - epidemiology ; COVID-19 ; Diagnosis ; Distribution ; Fever ; Fever - epidemiology ; Global Health ; Heterogeneity ; Humans ; Hyperthermia ; Laboratory tests ; Medical research ; Medicine and Health Sciences ; Medicine, Experimental ; Middle Aged ; Oxygenation ; Pandemics ; Physical Sciences ; Pneumonia, Viral - epidemiology ; Pneumonia, Viral - pathology ; Preprints as Topic ; Prevalence ; Quarantine ; Research and Analysis Methods ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Studies ; Ventilation ; Viral diseases
Is Part Of: PloS one, 2020-06, Vol.15 (6), p.e0234765-e0234765
Description: To limit the spread of SARS-CoV-2, an evidence-based understanding of the symptoms is critical to inform guidelines for quarantining and testing. The most common features are purported to be fever and a new persistent cough, although the global prevalence of these symptoms remains unclear. The aim of this systematic review is to determine the prevalence of symptoms associated with COVID-19 worldwide. We searched PubMed, Embase, CINAHL, AMED, medRxiv and bioRxiv on 5th April 2020 for studies of adults (>16 years) with laboratory test confirmed COVID-19. No language or publication status restrictions were applied. Data were independently extracted by two review authors into standardised forms. All datapoints were independently checked by three other review authors. A random-effects model for pooling of binomial data was applied to estimate the prevalence of symptoms, subgrouping estimates by country. I2 was used to assess inter-study heterogeneity. Of 851 unique citations, 148 articles were included which comprised 24,410 adults with confirmed COVID-19 from 9 countries. The most prevalent symptoms were fever (78% [95% CI 75%-81%]; 138 studies, 21,701 patients; I2 94%), a cough (57% [95% CI 54%-60%]; 138 studies, 21,682 patients; I2 94%) and fatigue (31% [95% CI 27%-35%]; 78 studies, 13,385 patients; I2 95%). Overall, 19% of hospitalised patients required non-invasive ventilation (44 studies, 6,513 patients), 17% required intensive care (33 studies, 7504 patients), 9% required invasive ventilation (45 studies, 6933 patients) and 2% required extra-corporeal membrane oxygenation (12 studies, 1,486 patients). The mortality rate was 7% (73 studies, 10,402 patients). We confirm that fever and cough are the most prevalent symptoms of adults infected by SARS-CoV-2. However, there is a large proportion of infected adults which symptoms-alone do not identify.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0234765
PMID: 32574165
Source: Public Library of Science (PLoS) Journals Open Access
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
Coronavirus Research Database
ProQuest Central
DOAJ Directory of Open Access Journals

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The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries

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