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Illuminating developmental biology through photochemistry

Nature chemical biology, 2017-05, Vol.13 (6), p.587-598 [Peer Reviewed Journal]

Copyright Nature Publishing Group Jun 2017 ;ISSN: 1552-4450 ;EISSN: 1552-4469 ;DOI: 10.1038/nchembio.2369 ;PMID: 28514427

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Title:
Illuminating developmental biology through photochemistry
Author: Kowalik, Lukasz ; Chen, James K
Subjects: Biochemistry ; Biological evolution ; Biologists ; Biology ; Chemistry ; Deoxyribonucleic acid ; Developmental biology ; Developmental Biology - instrumentation ; Developmental Biology - methods ; Developmental Biology - trends ; DNA ; DNA probes ; Gene sequencing ; Genomes ; Genomics ; Models, Biological ; Molecular Probes - metabolism ; Molecular Structure ; Photochemistry ; Photochemistry - trends ; Probes ; Proteins ; Rhodopsin - chemistry ; Ribonucleic acid ; RNA
Is Part Of: Nature chemical biology, 2017-05, Vol.13 (6), p.587-598
Description: Developmental biology has been continually shaped by technological advances, evolving from a descriptive science into one immersed in molecular and cellular mechanisms. Most recently, genome sequencing and 'omics' profiling have provided developmental biologists with a wealth of genetic and biochemical information; however, fully translating this knowledge into functional understanding will require new experimental capabilities. Photoactivatable probes have emerged as particularly valuable tools for investigating developmental mechanisms, as they can enable rapid, specific manipulations of DNA, RNA, proteins, and cells with spatiotemporal precision. In this Perspective, we describe optochemical and optogenetic systems that have been applied in multicellular organisms, insights gained through the use of these probes, and their current limitations. We also suggest how chemical biologists can expand the reach of photoactivatable technologies and bring new depth to our understanding of organismal development.
Publisher: United States: Nature Publishing Group
Language: English
Identifier: ISSN: 1552-4450
EISSN: 1552-4469
DOI: 10.1038/nchembio.2369
PMID: 28514427
Source: AUTh Library subscriptions: ProQuest Central
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Illuminating developmental biology through photochemistry

Copyright Nature Publishing Group Jun 2017 ;ISSN: 1552-4450 ;EISSN: 1552-4469 ;DOI: 10.1038/nchembio.2369 ;PMID: 28514427

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