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Numerical study of ultra-low field nuclear magnetic resonance relaxometry utilizing a single axis magnetometer for signal detection

Medical physics (Lancaster), 2013-05, Vol.40 (5), p.052301-n/a [Peer Reviewed Journal]

American Association of Physicists in Medicine ;2013 American Association of Physicists in Medicine ;ISSN: 0094-2405 ;EISSN: 2473-4209 ;DOI: 10.1118/1.4800491 ;PMID: 23635288 ;CODEN: MPHYA6

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Title:
Numerical study of ultra-low field nuclear magnetic resonance relaxometry utilizing a single axis magnetometer for signal detection
Author: Vogel, Michael W. ; Vegh, Viktor ; Reutens, David C.
Subjects: Arrangements or instruments for measuring magnetic variables ; biomedical MRI ; Coils ; finite element analysis ; Finite element calculations ; finite element method ; Involving electronic [emr] or nuclear [nmr] magnetic resonance, e.g. magnetic resonance imaging ; Magnetic field measurements ; Magnetic field sensors ; Magnetic fields ; Magnetic flux ; Magnetic resonance imaging ; Magnetic Resonance Spectroscopy - methods ; magnetometer ; magnetometers ; Magnetometers for magnetic field measurements ; Magnetometry - instrumentation ; Models, Theoretical ; nuclear magnetic resonance ; numerical simulation ; Position sensitive detectors ; Relaxation times ; relaxometry ; signal detection ; Spatial analysis ; Spatial dimensions ; ultralow field
Is Part Of: Medical physics (Lancaster), 2013-05, Vol.40 (5), p.052301-n/a
Description: Purpose: This paper investigates optimal placement of a localized single-axis magnetometer for ultralow field (ULF) relaxometry in view of various sample shapes and sizes. Methods: The authors used finite element method for the numerical analysis to determine the sample magnetic field environment and evaluate the optimal location of the single-axis magnetometer. Results: Given the different samples, the authors analysed the magnetic field distribution around the sample and determined the optimal orientation and possible positions of the sensor to maximize signal strength, that is, the power of the free induction decay. The authors demonstrate that a glass vial with flat bottom and 10 ml volume is the best structure to achieve the highest signal out of samples studied. Conclusions: This paper demonstrates the importance of taking into account the combined effects of sensor configuration and sample parameters for signal generation prior to designing and constructing ULF systems with a single-axis magnetometer. Through numerical simulations the authors were able to optimize structural parameters, such as sample shape and size, sensor orientation and location, to maximize the measured signal in ultralow field relaxometry.
Publisher: United States: American Association of Physicists in Medicine
Language: English
Identifier: ISSN: 0094-2405
EISSN: 2473-4209
DOI: 10.1118/1.4800491
PMID: 23635288
CODEN: MPHYA6
Source: MEDLINE
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Numerical study of ultra-low field nuclear magnetic resonance relaxometry utilizing a single axis magnetometer for signal detection

American Association of Physicists in Medicine ;2013 American Association of Physicists in Medicine ;ISSN: 0094-2405 ;EISSN: 2473-4209 ;DOI: 10.1118/1.4800491 ;PMID: 23635288 ;CODEN: MPHYA6

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